Abstract | BACKGROUND: We previously reported the secretion of apolipoprotein apoC-I, apoC-II, apoC-III, and apoE from adipose tissue in postmenopausal obese women, suggesting their potential regulation by energy balance in humans. OBJECTIVE: We examined the changes of these apolipoproteins, in relation to changes in cardiometabolic risks, following a hypocaloric diet in overweight/obese women. METHODS/RESULTS: A total of 137 postmenopausal overweight/obese women who were free of chronic disease were examined at baseline, 56 women of whom were reevaluated following a 6-month hypocaloric diet. At baseline, there was no association between the plasma transferable apolipoproteins with any index of adiposity, insulin sensitivity, lipids, or inflammation, except for apoE with peripheral fat mass (r = 0.18, P < .05), and apoC-II and apoC-III with cholesterol (r = 0.23 and r = 0.20 respectively, P < .05). The hypocaloric diet reduced adiposity, insulin resistance, and inflammatory markers but had no significant effects on plasma transferable apolipoproteins or lipids, whose average concentrations were within normal range at baseline. The changes in total and central, but not peripheral, fat mass associated with changes of apoC-I only (r = 0.28 and r = 0.43; respectively, P < .05). Post- weight-loss apoC-I increased in some women (52%) yet it decreased in others, however there were no differences in cardiometabolic risk factors between the 2 groups. CONCLUSIONS:
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Authors | Hanny Wassef, Jean Davignon, Denis Prud'homme, Rémi Rabasa-Lhoret, May Faraj |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2014 Sep-Oct
Vol. 8
Issue 5
Pg. 510-9
ISSN: 1933-2874 [Print] United States |
PMID | 25234564
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Apolipoprotein C-I
- Apolipoproteins E
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Topics |
- Adipose Tissue
(pathology)
- Aged
- Apolipoprotein C-I
(metabolism)
- Apolipoproteins E
(metabolism)
- Body Weight
- Diet, Reducing
- Female
- Humans
- Insulin Resistance
- Middle Aged
- Obesity
(diet therapy, metabolism, pathology)
- Postmenopause
(metabolism)
- Risk Factors
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