[N-stearoylethanolamine effect on the level of 11-hydroxycorticosteroids, cytokines IL-1, IL-6 and TNFalpha in rats with nonspecific inflammation caused by thermal burn of skin].

Abstract

The mechanisms of anti-inflammatory action of saturated N-acylethanolamine--N-stearoylethanolamine (NSE) were investigated on the rat model of nonspecific inflammation (thermal burns of the skin). The results showed that the NSE application in a form of aqueous suspension (10 mg/ml) on the damaged skin area during 12 days significantly accelerated the healing process of burned wounds. NSE also prevented the increase of 11-hydroxycorticosteroids content in the blood of rats with burns. There was also found a significant decrease of cytokines (IL-1beta, IL-6 and TNFalpha) levels under the NSE action. This way may be one of the mechanisms of NSE anti-inflammatory action.

• Authors: O D Zhukov, A H Berdyshev, H V Kosiakova, V M Klimashevs'kyĭ, T M Horid'ko, O F Mehed', N M Hula
• Journal: Ukrainian biochemical journal (Ukr Biochem J) 2014 May-Jun Vol. 86 Issue 3 Pg. 88-97 ISSN: 2409-4943 [Print] Ukraine
• PMID: 25033558 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 11-Hydroxycorticosteroids
• Anti-Inflammatory Agents, Non-Steroidal
• Ethanolamines
• Interleukin-1beta
• Interleukin-6
• N-acylethanolamines
• N-stearoylethanolamine
• Stearic Acids
• Tumor Necrosis Factor-alpha

Topics

• 11-Hydroxycorticosteroids (blood)
• Administration, Cutaneous
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Burns (blood, drug therapy, immunology, pathology)
• Ethanolamines (pharmacology)
• Hot Temperature
• Inflammation (blood, drug therapy, immunology, pathology)
• Interleukin-1beta (blood)
• Interleukin-6 (blood)
• Male
• Rats
• Rats, Wistar
• Skin (drug effects, immunology, injuries)
• Stearic Acids (pharmacology)
• Tumor Necrosis Factor-alpha (blood)
• Wound Healing (drug effects, physiology)