Acquired atopic disease after liver transplantation in children; similarities to and differences from adults: a preliminary study.

Abstract

OBJECTIVE:

The aim of this study was to determine the similarities and differences in the frequency and follow-ups of newly diagnosed atopic diseases after liver transplantation in pediatric and adult patients.

MATERIALS AND METHODS:

Patients who underwent liver transplants between 2005 and 2013 and who are still alive were enrolled in the study. Patients who came for checkups filled out a survey evaluating atopic diseases. Those who had an atopic disease before transplantation were excluded from the study.

RESULTS:

A total of 165 patients were enrolled in this study; 114 (69.1%) were males and 29 (17.6%) were children. The average transplantation age was 40.8 (0.3-67) years, and the most frequent reason for transplantation was chronic viral hepatitis. In 22 patients, atopic diseases [allergic rhinitis in nine patients (5.5%), asthma in six patients (3.9%), atopic eczema in six patients (3.9%), food allergy in six patients (3.9%), and drug allergy in one patient (0.6%)] developed after transplantation. Atopic diseases after transplantation were more common in children (P=0.03). When the atopic diseases were examined on a case-by-case basis, there were no differences between children and adults with respect to asthma (P=0.284), allergic rhinitis (P=1.0), or atopic eczema (P=0.284), but food allergy (P=0.009) and peripheral eosinophilia (P=0.002) were more common in children. The periodicity of allergic diseases after transplantation (P=0.192) and total IgE levels (P=0.086) were similar.

CONCLUSION:

Atopic diseases developed after liver transplantation and had a greater impact on children than adults. Therefore, after undergoing liver transplantation, patients should be monitored closely for signs of atopic diseases.

• Authors: Erdem Topal, Ferhat Çatal, Mukadder Ayşe Selimoğlu, Hamza Karabiber, Talat Klc, Adil Başkran, Elif Senbaba, Sezai Ylmaz
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 26 Issue 9 Pg. 1055-9 (Sep 2014) ISSN: 1473-5687 [Electronic] England
• PMID: 24949707 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin E

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Child
• Child, Preschool
• Female
• Follow-Up Studies
• Hepatitis, Viral, Human (surgery)
• Humans
• Hypersensitivity, Immediate (etiology, immunology)
• Immunoglobulin E (blood)
• Infant
• Liver Transplantation (adverse effects, methods)
• Male
• Middle Aged
• Postoperative Period
• Risk Factors
• Young Adult