Energy expenditure, spontaneous physical activity and with weight gain in kidney transplant recipients.

Abstract

BACKGROUND & AIMS:

Alterations in energy metabolism could trigger weight gain after renal transplantation.

METHODS:

Nineteen transplanted non-diabetic men, 53 ± 1.6 years old, receiving calcineurin inhibitors but no corticosteroids were studied. They were compared with nine healthy men matched for height, age and lean body mass. Daily energy expenditure and its components (sleeping, basal and absorptive metabolic rates) were analyzed for 24 h in calorimetric chambers and for 4 days in free living conditions using calibrated accelerometry. Other variables known to influence energy expenditure were assessed: body composition, physical activity, 4-day food intake, drug consumption, serum C-reactive protein, interleukin-6, thyroid and parathyroid hormones, and epinephrine. Transplant recipients who gained more than 5% body weight after transplantation (n = 11, +11.0 ± 1.5 kg) were compared with those who did not (n = 8) and with the controls.

RESULTS:

Weight gain compared with non-weight gain patients and controls exhibited higher fat mass without change in lean body mass. Daily, sleeping and resting energy expenditure adjusted for lean body mass was significantly higher in non-weight gain (167.1 ± 4.2 kJ/kg/lean body mass/24 h, P < 0.05) compared with weight gain patients (147.4 ± 3.6) and controls (146.1 ± 4.6). Weight gain compared with controls and non-weight gain subjects had lower free living physical activity and a higher consumption of antihypertensive drugs and β-blockers.

CONCLUSIONS:

After kidney transplantation, weight gain patients were characterized by lower adjusted energy expenditure, reduced spontaneous physical activity but a more sedentary life style and a trend toward a higher energy intake explaining the reason they gained weight. The nWG KTR had increased resting and sleeping EE which protected them from weight gain. Such hypermetabolism was also observed in 24-h EE measurements. By comparison with the nWG patients, the WG transplant recipients were characterized by higher β-blocker consumption. These data could be helpful in the prevention of weight gain in kidney transplant recipients.

• Authors: Anne-Elisabeth Heng, Christophe Montaurier, Noël Cano, Nicolas Caillot, A Blot, Nathalie Meunier, Bruno Pereira, Geoffroy Marceau, Vincent Sapin, Christelle Jouve, Yves Boirie, Patrice Deteix, Beatrice Morio
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 34 Issue 3 Pg. 457-64 (Jun 2015) ISSN: 1532-1983 [Electronic] England
• PMID: 24928604 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014. Published by Elsevier Ltd.

Chemical References

• Hemoglobins
• Interleukin-6
• Parathyroid Hormone
• Prealbumin
• Serum Albumin
• Thyroid Hormones
• Triglycerides
• C-Reactive Protein
• Cholesterol
• Creatinine
• Norepinephrine

Topics

• Basal Metabolism
• Body Composition
• Body Mass Index
• Body Weight
• C-Reactive Protein (metabolism)
• Case-Control Studies
• Cholesterol (blood)
• Creatinine (blood)
• Energy Intake
• Energy Metabolism
• Hemoglobins (metabolism)
• Humans
• Interleukin-6 (blood)
• Kidney (surgery)
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation
• Male
• Middle Aged
• Motor Activity
• Norepinephrine (blood)
• Parathyroid Hormone (blood)
• Prealbumin (metabolism)
• Sedentary Behavior
• Serum Albumin (metabolism)
• Surveys and Questionnaires
• Thyroid Hormones (blood)
• Transplant Recipients
• Triglycerides (blood)
• Weight Gain