Abstract | BACKGROUND: P53 protein expression has been detected immunohistochemically in papillary thyroid carcinoma(PTC). We investigated the relations between its expression and clinicopathologic features and its significance as a diagnostic marker. MATERIALS AND METHODS: RESULTS: Statistical analysis showed significantly different expression of p53 in PTC versus other benign thyroid lesions (BTL).The diagnostic sensitivity and specificity were 85.0% and 72.7%, respectively. Overexpression of p53 protein was observed in 44 of the 93 PTC cases (47.3%), but no significant correlation between p53 protein overexpression and clinicopathologic features (age, size, multiplicity, lymph node metastasis, extrathyroidal extension and vascular invasion) was noted. CONCLUSIONS: p53 is valuable to distinguish PTC from other BTL, but there is no correlation between p53 protein overexpression and clinicopathologic features.
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Authors | Mi Kyung Shin, Jeong Won Kim |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 15
Issue 5
Pg. 2341-4
( 2014)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 24716981
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Tumor Suppressor Protein p53
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Topics |
- Biomarkers, Tumor
(metabolism)
- Carcinoma
(metabolism, pathology, surgery)
- Carcinoma, Papillary
- Case-Control Studies
- Female
- Humans
- Lymph Nodes
(metabolism, pathology)
- Male
- Middle Aged
- Thyroid Cancer, Papillary
- Thyroid Gland
(metabolism, pathology)
- Thyroid Neoplasms
(metabolism, pathology, surgery)
- Thyroidectomy
(methods)
- Tumor Suppressor Protein p53
(metabolism)
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