Expression of RABEX-5 and its clinical significance in prostate cancer.

Abstract

BACKGROUND:

While recent research has shown that expression of RABEX-5 in breast cancer and colorectal cancer has a crucial impact on tumor development, there is little information regarding RABEX-5 expression in prostate cancer. This study investigated the expression of RABEX-5 in prostate cancer by real time quantitative polymerase chain reaction and evaluated its association with clinicopathological variables, including prostate cancer patient prognosis.

METHODS:

A total of 180 patients with primary prostate cancer treated by radical prostatectomy were enrolled. Real time quantitative polymerase chain reaction was utilized to investigate mRNA expression level of RABEX-5 in 180 paired prostate cancer/adjacent non-cancerous tissues. RABEX-5 mRNA expression was divided into high expression group and low expression group and correlations between RABEX-5 mRNA and clinicopathological factors were then evaluated. Kaplan-Meier plots and Cox proportional hazards regression model were used to analyze the association between RABEX-5 mRNA expression and prognosis of patients with prostate cancer.

RESULTS:

Our study showed that RABEX-5 mRNA was significantly upregulated in prostate cancer tissues. The data indicated that high expression of RABEX-5 mRNA was significantly associated with lymph node metastasis (P = 0.001), clinical stage (P = 0.004), biochemical recurrence (P = 0.009), preoperative prostate-specific antigen (P < 0.001), and Gleason score (P < 0.001). High RABEX-5 mRNA expression was a significant predictor of poor biochemical recurrence free survival and overall survival both in univariate and multivariate analysis.

CONCLUSION:

This is to our knowledge the first report investigating tumor RABEX-5 mRNA expression level in prostate cancer. We have shown that high RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy, and multivariate analysis confirmed RABEX-5 mRNA as an independent prognostic factor.

• Authors: Hongtuan Zhang, Shang Cheng, Andi Wang, Hui Ma, Bing Yao, Can Qi, Ranlu Liu, Shiyong Qi, Yong Xu
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 33 Pg. 31 (Apr 09 2014) ISSN: 1756-9966 [Electronic] England
• PMID: 24716822 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Guanine Nucleotide Exchange Factors
• RABGEF1 protein, human
• RNA, Messenger

Topics

• Aged
• Disease-Free Survival
• Gene Expression
• Guanine Nucleotide Exchange Factors (genetics, metabolism)
• Humans
• Kaplan-Meier Estimate
• Male
• Multivariate Analysis
• Prognosis
• Proportional Hazards Models
• Prostate (metabolism, pathology)
• Prostatectomy
• Prostatic Neoplasms (metabolism, mortality, surgery)
• RNA, Messenger (genetics, metabolism)
• Treatment Outcome