Mechanisms mediating renal sympathetic nerve activation in obesity-related hypertension.

Abstract

Excessive renal sympathetic nerve activation may be one of the mechanisms underlying obesity-related hypertension. Impaired baroreflex sensitivity, adipokine disorders-such as leptin, adiponectin, and resistin-activation of the renin-angiotensin system, hyperinsulinemia, insulin resistance, and renal sodium retention present in obesity increase renal sympathetic nerve activity, thus contributing to the development of hypertension. Renal sympathetic denervation reduces both renal sympathetic activity and blood pressure in patients with obesity-related hypertension.

• Authors: W Chen, S Leo, C Weng, X Yang, Y Wu, X Tang
• Journal: Herz (Herz) Vol. 40 Suppl 2 Pg. 190-6 (Apr 2015) ISSN: 1615-6692 [Electronic] Germany
• PMID: 24609799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Animals
• Baroreflex
• Blood Pressure
• Humans
• Hypertension (physiopathology)
• Kidney (innervation, physiopathology)
• Models, Cardiovascular
• Obesity (complications, physiopathology)
• Sympathetic Nervous System (physiopathology)