Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome.

Abstract

BACKGROUND/AIMS:

Oxidative stress increases the risk of cardiovascular complications of metabolic syndrome (MetS). This study was conducted to examine the difference in antioxidant capacity according to the presence of MetS, and to characterize the association between antioxidant capacity and MetS-related factors.

METHODS:

We used the biological antioxidant potential (BAP) test to estimate antioxidant capacity. The BAP test has recently been used as an indicator of antioxidant capacity. We measured BAP levels in 45 patients with MetS (mean age, 44.6 ± 1.1 years) and 47 age- and sex-matched controls (mean age, 42.7 ± 1.1 years). To evaluate the association between antioxidant capacity and MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-α, and homeostatic model assessment for insulin resistance (HOMA-IR), linear regression and logistic analyses were performed.

RESULTS:

The mean BAP of the MetS group (1,937.3 ± 36.5 µmol/L) was significantly lower than that of the non-MetS group (2,101.7 ± 29.5 µmol/L). Also, the mean BAP was low in persons having low high density lipoprotein and high triglyceride. Reduced antioxidant capacity was significantly associated with adiponectin, HOMA-IR and hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 2.75), respectively.

CONCLUSIONS:

Persons with MetS showed reduced antioxidant capacity. We identified relationships between antioxidant capacity measured by BAP test and MetS, as well as MetS-related factors, such as insulin resistance, hs-CRP, and adiponectin.

• Authors: Jung Hee Kim, Hyun Wook Baik, Yeong Sook Yoon, Hyo Jee Joung, Ju Sang Park, Sang Jong Park, Eun Jeong Jang, Sang Woon Park, Sang Jung Kim, Mi Jeoung Kim, Dong Ok Jeon, Hyo Jin Cho, Sang Jin Lee, Sung Gyu Im, Sun Kyung Jang
• Journal: The Korean journal of internal medicine (Korean J Intern Med) Vol. 29 Issue 1 Pg. 31-9 (Jan 2014) ISSN: 2005-6648 [Electronic] Korea (South)
• PMID: 24574831 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adipokines
• Antioxidants
• Biomarkers
• IL6 protein, human
• Interleukin-6
• Tumor Necrosis Factor-alpha
• C-Reactive Protein

Topics

• Adipokines (blood)
• Adult
• Antioxidants (metabolism)
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Case-Control Studies
• Female
• Humans
• Insulin Resistance
• Interleukin-6 (blood)
• Male
• Metabolic Syndrome (blood)
• Middle Aged
• Predictive Value of Tests
• Tumor Necrosis Factor-alpha (blood)