Reactive neutrophilic dermatoses associated with nontuberculous mycobacterial infection in adult-onset immunodeficiency syndrome responded well to acitretin: four cases report.

Abstract

BACKGROUND:

Recent articles have suggested an adult-onset immunodeficiency syndrome that was described in HIV-uninfected adults with disseminated non-tuberculous mycobacterial infection and/or another opportunistic infection with concomitant reactive dermatoses. Few studies reported the drugs used to treat these reactive neutrophilic dermatoses including systemic steroid, etretinate, clofazimine, colchicine, and dapsone. This study aims to report the efficacy of acitretin for the treatment of this condition.

MATERIAL AND METHOD:

Four HIV-uninfected patients with disseminated non-tuberculous mycobacterial infection and the reactive dermatoses from department of internal medicine, Maharaj Nakorn Chiang Mai Hospital between 2008 through 2011 were observed in the clinical presentation and course of disease including treatment and response.

RESULTS:

All patients had at least one episode of reactive dermatoses with variable presentations comprising Sweet's syndrome with pustules, pustular vasculitis-like lesions, or generalized pustular lesions. Acitretin was prescribed to treat these reactive neutrophilic dermatoses. It showed a good response without side effects.

CONCLUSION:

Acitretin, a second-generation retinoid, can be used for the treatment of reactive pustular lesions in the syndrome of adult-onset immunodeficiency due to its good response, being well tolerated, and without immunosuppression.

• Authors: Siri Chiewchanvit, Mati Chuamanochan, Pongsak Mahanupab, Vilai Baosoung
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 96 Issue 12 Pg. 1609-16 (Dec 2013) ISSN: 0125-2208 [Print] Thailand
• PMID: 24511727 (Publication Type: Case Reports, Journal Article)

Chemical References

• Keratolytic Agents
• Acitretin

Topics

• Acitretin (therapeutic use)
• Common Variable Immunodeficiency (drug therapy, immunology)
• Female
• Humans
• Keratolytic Agents (therapeutic use)
• Male
• Middle Aged
• Mycobacterium Infections, Nontuberculous (drug therapy, immunology)
• Sweet Syndrome (drug therapy, immunology)