Dapsone

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1518 relevant articles (137 outcomes, 146 trials/studies) found for this Drug

Description: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

Also Known As:

4,4'-Diaminophenyl Sulfone; Avlosulfone; DADPS; Dapsoderm-X; Dapson-Fatol; Diaphenylsulfone; Disulone; Fatol Brand of Dapsone; Mex-America Brand of Dapsone; Orsade Brand of Dapsone; Sulfona; 4,4' Diaminophenyl Sulfone; Sulfone, 4,4'-Diaminophenyl; Diaminodiphenylsulfone; Sulfonyldianiline

Relationship Network

Drug Context: Research Results

Experts

1.	Garrett, Steven: 4 articles (02/2008 - 01/2007)
2.	Maloney, J Michael: 3 articles (02/2008 - 03/2007)
3.	United States/Canada Dapsone Gel Study Group: 2 articles (02/2008 - 03/2007)
4.	Albrecht, Joerg: 2 articles (01/2008 - 06/2005)
5.	Werth, Victoria P: 2 articles (01/2008 - 06/2005)
6.	Hashimoto, T: 2 articles (05/2007 - 11/2001)
7.	Nader-Kawachi, Juan: 2 articles (04/2007 - 03/2004)
8.	Ríos, Camilo: 2 articles (04/2007 - 03/2004)
9.	Takiuchi, Arley: 2 articles (10/2005 - 02/2005)
10.	Khanna, N: 2 articles (07/2005 - 07/2001)

Related Diseases

1.	Leprosy (Hansen's Disease) 10/01/1994 - "Dapsone monotherapy is highly effective in the treatment of multibacillary leprosy under the conditions of well-controlled treatment. " 09/01/1999 - "6) In cases cured with dapsone therapy, there was an increase or a persistence of high OD values in ND-ELISA prior to the onset of a leprosy relapse. " 06/01/2009 - "OBJECTIVE: The study aimed to analyse the effect on the relapse rate of dapsone-cured multibacillary (MB) leprosy patients, of re-treatment, using a multidrug therapy (MDT) regimen which differed from the WHO recommended regimen. " 06/01/2009 - "leprae threatened leprosy control programmes, and increased the relapse rate of patients cured with dapsone monotherapy. " 03/01/2002 - "Serial antibody levels were measured in 666 leprosy patients after being cured with dapsone monotherapy. " Order ALL the reference details at left...
2.	Infection 08/01/1993 - "Dapsone is well-tolerated in children and appears to be as effective in preventing PCP in children with human immunodeficiency virus infection as it is in adults." 04/01/1989 - "However, treatment with dapsone (DDS) in the last 12 weeks of infection resulted in an initial enhancement of the humoral responses followed by a gradual decrease, though they were still significantly high at the end of the study." 09/01/1985 - "Studies were undertaken in three independent centers to compare the newer, in vitro radiometric macrophage (M phi) assay with the conventional mouse foot pad infection for the diagnosis of dapsone resistance. " 09/01/1952 - "[Action of diaminodiphenylsulfone on Nocardia brasiliensis; studies in vitro, in experimental infection and in the clinic.]" 08/01/2003 - "First-line therapy includes dapsone, as well as treatment of any underlying cause or infection." Order ALL the reference details at left...
3.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 05/01/1999 - "Toxicity and efficacy of daily vs. weekly dapsone for prevention of Pneumocystis carinii pneumonia in children infected with human immunodeficiency virus. " 01/01/2000 - "Were considered as eligible: randomized clinical trials, conducted in adults, with one arm evaluating dapsone as prophylactic agent for Pneumocystis Carinii Pneumonia (PCP). " 01/01/1991 - "We conclude that high-dose, single-agent dapsone is not suitable for further study as therapy for Pneumocystis carinii pneumonia." 01/01/1991 - "In a prospective, noncomparative study, seven patients with mild Pneumocystis carinii pneumonia, characterized by room air arterial PO2 greater than 60 mm Hg at the time of presentation, were treated with dapsone alone at a dose of 200 mg daily. " 09/01/2006 - "Dapsone is commonly used for pneumocystis carinii pneumonia (PCP) prophylaxis in immunocompromised patients. " Order ALL the reference details at left...
4.	Acne Vulgaris 10/01/2007 - "These results show that dapsone gel 5% is safe and effective for long-term treatment of acne vulgaris and has a rapid onset of action." 03/01/2007 - "CONCLUSIONS: Dapsone gel, 5% appears to be an effective, safe, and well-tolerated treatment for acne vulgaris, with a rapid onset of action." 06/01/2009 - "RESULTS/CONCLUSIONS: Clinical studies indicate dapsone gel 5% is effective in treating mild to moderately severe acne. " 10/01/2007 - "Dapsone gel 5%, a topical formulation of dapsone, was shown to deliver clinically effective doses of dapsone with minimal systemic absorption in 2 randomized, vehicle-controlled, 12-week studies of patients with acne vulgaris. " 01/01/2009 - "Based on the observations noted in the above-mentioned studies, we conclude that topical dapsone 5% gel is safe and effective in the treatment of acne vulgaris." Order ALL the reference details at left...
5.	Skin Diseases 01/01/1995 - "Dapsone (4,4'-diaminodiphenylsulfone) is effective in treating inflammatory skin diseases. " 08/01/2006 - "PATIENTS AND METHODS: Case n degrees 1. A 51-year-old man was treated with Disulone for a neutrophilic skin disease. " 05/01/2005 - "BACKGROUND: Dapsone (4,4'-diaminodiphenyl sulphone) is a powerful therapeutic tool in many skin diseases including neutrophilic dermatoses. " 11/01/2003 - "[Dapsone in skin diseases]" 06/01/2002 - "Dapsone (4,4'-diaminodiphenylsulfone, DDS) was synthesized a century ago and continues to be a powerful therapeutic tool in many skin diseases. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Pyrimethamine (Daraprim)
2.	Rifampin (Rifampicin)
3.	Pentamidine (NebuPent)
4.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
5.	Chloroquine (Aralen)
6.	Trimethoprim (Proloprim)
7.	Immunoglobulin A (IgA)
8.	Primaquine
9.	Clofazimine (Lamprene)
10.	Chloroguanide (Proguanil)

Related Therapies and Procedures

1.	Injections
2.	Renal Dialysis (Hemodialysis)
3.	Drug Therapy (Chemotherapy)
4.	Chemoprevention
5.	Aftercare (After-Treatment)

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