Abstract | OBJECTIVE:
Leptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high- sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as well as the associated changes in mRNA levels in hypothalamic and mesolimbic brain areas. DESIGN AND METHODS: RESULTS: ICV leptin decreased caloric intake both in CHOW and fcHFHS rats. In fcHFHS, leptin preferentially decreased chow and fat intake. Leptin increased POMC and decreased NPY mRNA in CHOW, but not in fcHFHS rats. In CHOW rats, leptin had no effect on ppENK mRNA and decreased TH mRNA. In fcHFHS, leptin decreased ppENK mRNA and increased TH mRNA. CONCLUSION: Despite peripheral and arcuate leptin resistance, central leptin suppresses feeding in fcHFHS rats. As the VTA and nucleus accumbens are still responsive to leptin, these brain areas may therefore, at least partly, account for the leptin-induced feeding suppression in rats on a fcHFHS diet.
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Authors | José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur |
Journal | PloS one
(PLoS One)
Vol. 9
Issue 1
Pg. e87729
( 2014)
ISSN: 1932-6203 [Electronic] United States |
PMID | 24498181
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Carbohydrates
- Dietary Fats
- Leptin
- Nerve Tissue Proteins
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Topics |
- Animals
- Arcuate Nucleus of Hypothalamus
(metabolism)
- Dietary Carbohydrates
(pharmacology)
- Dietary Fats
(pharmacology)
- Feeding Behavior
(drug effects)
- Gene Expression Regulation
(drug effects)
- Leptin
(metabolism, pharmacology)
- Male
- Nerve Tissue Proteins
(biosynthesis)
- Rats
- Rats, Wistar
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