Clinical implications of the interleukin 27 serum level in breast cancer.

Abstract

INTRODUCTION:

Interleukin 27 (IL-27), belonging to the IL-12 family, exerts a critical role in immune regulation of infection, autoimmunity, and tumor. In this study, we aimed to investigate the roles of IL-27 and vascular endothelial growth factor (VEGF) in breast cancer.

METHODS:

The serum levels of IL-27 and VEGF in 150 patients with breast cancer and 90 control subjects were measured by an enzyme-linked immunosorbent assay. Estrogen receptor, progesterone receptor, and human epithelial growth factor receptor 2 were measured by immunohistochemistry. Clinical stage, tumor size, lymph node metastasis, grade, and histological type were also recorded.

RESULTS:

The serum levels of IL-27 and VEGF were significantly greater in breast cancer patients than in the control group. In addition, there was a significant correlation between IL-27 and VEGF, and serum IL-27 and VEGF levels were associated with the clinical stage of breast cancer. Moreover, the serum levels of IL-27 were especially elevated in breast cancer patients who were estrogen receptor-positive and progesterone receptor-positive. Furthermore, the serum levels of IL-27 and VEGF decreased after patients with breast cancer had modified radical mastectomy.

CONCLUSION:

Interleukin 27 may be a new prognostic biomarker of breast cancer and a promising target to limit both angiogenesis and tumor growth.

• Authors: Dapeng Lu, Xiangyu Zhou, Lutian Yao, Caigang Liu, Feng Jin, Yunfei Wu
• Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research (J Investig Med) Vol. 62 Issue 3 Pg. 627-31 (Mar 2014) ISSN: 1708-8267 [Electronic] England
• PMID: 24448601 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Estrogen Receptor alpha
• Interleukins
• MYDGF protein, human
• Receptors, Progesterone
• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Adult
• Biomarkers, Tumor (blood)
• Breast Neoplasms (blood, diagnosis, surgery)
• Estrogen Receptor alpha (blood)
• Female
• Humans
• Interleukins (blood)
• Middle Aged
• Receptors, Progesterone (blood)
• Vascular Endothelial Growth Factor A (blood)