Overexpression of kallikrein gene 10 is a biomarker for predicting poor prognosis in gastric cancer.

Abstract

AIM:

To analyze the expression of kallikrein gene 10 (KLK10) in gastric cancer and to determine whether KLK10 has independent prognostic value in gastric cancer.

METHODS:

We studied KLK10 expression in 80 histologically confirmed gastric cancer samples using real-time quantitative reverse transcription-PCR and hK10 expression using immunohistochemistry. Correlations with clinicopathological variables (lymph node metastasis, depth of invasion and histology) and with outcomes (disease-free survival and overall survival) during a median follow-up period of 31 mo were assessed. Gastric cancer tissues were then classified as KLK10 positive or negative.

RESULTS:

KLK10 was found to be highly expressed in 57/80 (70%) of gastric cancer samples, while its expression was very low in normal gastric tissues. Positive relationships between KLK10 expression and lymph node metastasis (P = 0.048), depth of invasion (P = 0.034) and histology (P = 0.015) were observed. Univariate survival analysis revealed that gastric cancer patients with positive KLK10 expression had an increased risk for relapse/metastasis and death (P = 0.005 and 0.002, respectively). Cox multivariate analysis indicated that KLK10 was an independent prognostic indicator of disease-free survival and overall survival in patients with gastric cancer.

CONCLUSION:

KLK10 expression is an independent biomarker of unfavorable prognosis in patients with gastric cancer.

• Authors: Xin Jiao, Hong-Jun Lu, Mi-Mi Zhai, Zhi-Jun Tan, Hai-Ning Zhi, Xiao-Man Liu, Chen-Hao Liu, Da-Peng Zhang
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 19 Issue 48 Pg. 9425-31 (Dec 28 2013) ISSN: 2219-2840 [Electronic] United States
• PMID: 24409072 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• RNA, Messenger
• KLK10 protein, human
• Kallikreins

Topics

• Adult
• Aged
• Biomarkers, Tumor (analysis, genetics)
• Chi-Square Distribution
• Disease-Free Survival
• Female
• Humans
• Immunohistochemistry
• Kallikreins (analysis, genetics)
• Kaplan-Meier Estimate
• Lymphatic Metastasis
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Invasiveness
• Predictive Value of Tests
• Proportional Hazards Models
• RNA, Messenger (analysis)
• Real-Time Polymerase Chain Reaction
• Reverse Transcriptase Polymerase Chain Reaction
• Risk Factors
• Stomach Neoplasms (enzymology, genetics, mortality, pathology, therapy)
• Time Factors
• Treatment Outcome
• Up-Regulation