Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in the Landrace line influences the expression of soluble factors in blood after MPS vaccine sensitization.

Abstract

We recently developed a Landrace line that is resistant to mycoplasmal pneumonia of swine (MPS) infection by genetic selection for five generations, and we reported that the immunophenotype of this line is different from that of the non-selected line in terms of changes in peripheral blood leukocyte population after MPS vaccination. This study followed up previous findings demonstrating changes in soluble factors in blood, namely, hormones, Mycoplasma hyopneumoniae-specific immunoglobulin G (IgG), and cytokines. These two lines were injected with MPS vaccine on days -7 and 0 after blood sampling on those days, and blood samples were collected on days -14, -7, 0, 2, 7 and 14. We found changes in the levels of many hormones and cytokines in both lines. However, we found that only growth hormone (GH) and interferon (IFN)-γ levels were statistically different between these two lines. GH concentration was reduced (day 0) and IFN-γ concentration was increased (day 14) in the MPS-selected line compared with the non-selected line, despite unchanged IFN-γ messenger RNA expression in blood cells. Although detailed mechanisms underlying these phenotypes remain unsolved, these traits would be useful to improve MPS resistance in pig production and provide an insight into MPS infection.

• Authors: Tomoyuki Shimazu, Liushiqi Borjigin, Yuki Katayama, Meihua Li, Takumi Satoh, Kouichi Watanabe, Haruki Kitazawa, Sang-gun Roh, Hisashi Aso, Katoh Kazuo, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki
• Journal: Animal science journal = Nihon chikusan Gakkaiho (Anim Sci J) Vol. 85 Issue 4 Pg. 365-73 (Apr 2014) ISSN: 1740-0929 [Electronic] Australia
• PMID: 24329865 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Japanese Society of Animal Science.

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines
• Cytokines
• Immunoglobulin G
• Interferon-gamma
• Growth Hormone

Topics

• Animals
• Antibodies, Bacterial (blood)
• Bacterial Vaccines (immunology)
• Cytokines (blood)
• Genetic Predisposition to Disease (genetics)
• Growth Hormone (blood)
• Humans
• Immunization
• Immunoglobulin G (blood)
• Interferon-gamma (blood)
• Male
• Mycoplasma hyopneumoniae (immunology)
• Pneumonia of Swine, Mycoplasmal (genetics, immunology)
• Selection, Genetic (genetics)
• Swine (genetics, immunology)