Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.

Abstract

OBJECTIVE:

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has been established as a reliable and potential biomarker of neuronal damage after acute neurologic insults, such as ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury. However, the effect of serum UCH-L1 levels has not been investigated in carbon monoxide (CO)-poisoned patients. The aim of the present study was to evaluate whether serum UCH-L1 levels are a reliable marker of brain damage and the association of UCH-L1 with outcome.

DESIGN AND METHODS:

This case-control study enrolled 46 CO-poisoned subjects and 30 controls. Using an enzyme-linked immunosorbent assay (ELISA) kit, we studied the temporal profile of serum UCH-L1 levels at 6, 12, 24 and 48 h after acute CO poisoning. Poisoning severity was assessed using the Glasgow Coma Scale (GCS) score. Long-term outcome was assessed using the Glasgow Outcome Scale (GOS) at 6 months after poisoning.

RESULTS:

Compared with controls, CO-poisoned patients had significantly elevated serum levels of UCH-L1 at each time point after poisoning. There were significantly higher levels of UCH-L1 in CO-poisoned patients with a lower GCS score as well as in those with a poor 6-month outcome dichotomized GOS.

CONCLUSIONS:

Serum levels of UCH-L1 appear to have potential clinical utility in providing valuable information about poisoning severity and outcome after CO poisoning.

• Authors: Li Pang, Yang Wu, Ning Dong, Da-hai Xu, Da-wei Wang, Zhi-hao Wang, Xing-liang Li, Miao Bian, Hui-jie Zhao, Xiao-liang Liu, Nan Zhang
• Journal: Clinical biochemistry (Clin Biochem) Vol. 47 Issue 1-2 Pg. 72-6 (Jan 2014) ISSN: 1873-2933 [Electronic] United States
• PMID: 24080464 (Publication Type: Journal Article)
• Copyright: © 2013.

Chemical References

• UCHL1 protein, human
• Ubiquitin Thiolesterase

Topics

• Adult
• Carbon Monoxide Poisoning (blood, enzymology)
• Case-Control Studies
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Ubiquitin Thiolesterase (blood)
• Young Adult