Abstract | BACKGROUND: METHODS AND RESULTS: The Study of Coronary Atheroma by Intravascular Ultrasound: Effect of Rosuvastatin Versus Atorvastatin (SATURN) used serial intravascular ultrasound measures of coronary atheroma volume in patients treated with rosuvastatin 40 mg or atorvastatin 80 mg for 24 months. The treatment groups did not differ significantly in the change from baseline of percent atheroma volume on intravascular ultrasound, CRP-modulating effects, or MACE rates, thus allowing for a (prespecified) post hoc analysis to test associations between the changes in CRP levels with coronary disease progression and MACE. Patients with nonincreasing CRP levels (n=621) had higher baseline (2.3 [1.1-4.7] versus 1.1 [0.5-1.8] mg/L; P<0.001) and lower follow-up CRP levels (0.8 [0.5-1.7] versus 1.6 [0.7-4.1] mg/L; P<0.001) versus those with increasing CRP levels (n=364). Multivariable analysis revealed a nonincreasing CRP level to independently associate with greater percent atheroma volume regression (P=0.01). Although the (log) change in CRP did not associate with MACE (hazard ratio, 1.18; 95% confidence interval, 0.93-1.50; P=0.17), the (log) on-treatment CRP associated significantly with MACE (hazard ratio, 1.28; 95% confidence interval, 1.04-1.56; P=0.02). On-treatment low-density lipoprotein cholesterol levels did not correlate with MACE (hazard ratio, 1.09; 95% confidence interval, 0.88-1.35; P=0.45). CONCLUSIONS: CLINICAL TRIAL REGISTRATION URL: http://clinicaltrials.gov. Unique identifier: NCT000620542.
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Authors | Rishi Puri, Steven E Nissen, Peter Libby, Mingyuan Shao, Christie M Ballantyne, Phillip J Barter, M John Chapman, Raimund Erbel, Joel S Raichlen, Kiyoko Uno, Yu Kataoka, Stephen J Nicholls |
Journal | Circulation
(Circulation)
Vol. 128
Issue 22
Pg. 2395-403
(Nov 26 2013)
ISSN: 1524-4539 [Electronic] United States |
PMID | 24043299
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, LDL
- Fluorobenzenes
- Heptanoic Acids
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Lipoproteins, LDL
- Pyrimidines
- Pyrroles
- Sulfonamides
- Rosuvastatin Calcium
- C-Reactive Protein
- Atorvastatin
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Topics |
- Aged
- Atorvastatin
- C-Reactive Protein
(metabolism)
- Cholesterol, LDL
(metabolism)
- Coronary Artery Disease
(drug therapy, metabolism, mortality)
- Female
- Fluorobenzenes
(administration & dosage)
- Follow-Up Studies
- Heptanoic Acids
(administration & dosage)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(administration & dosage)
- Kaplan-Meier Estimate
- Lipoproteins, LDL
(metabolism)
- Male
- Middle Aged
- Multivariate Analysis
- Proportional Hazards Models
- Pyrimidines
(administration & dosage)
- Pyrroles
(administration & dosage)
- Rosuvastatin Calcium
- Sulfonamides
(administration & dosage)
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