Severe acute rhabdomyolysis induced by multi-agent chemotherapy for alveolar rhabdomyosarcoma in a 15-year-old female: a case report.

Abstract

This is the first paper to report the association of cancer chemotherapy with rhabdomyolysis in children. A previously healthy, 15-year-old Japanese female was diagnosed as having alveolar rhabdomyosarcoma. She received the first cycle of multi-agent chemotherapy without any adverse effects. However, she developed severe acute rhabdomyolysis shortly after the second cycle of multi-agent chemotherapy, which consisted of etoposide, ifosfamide, actinomycin-D and vincristine. Her condition deteriorated rapidly and she was treated with mechanical ventilation and fluid replacement. After further evaluation, anticancer drugs were thought to be responsible for the rhabdomyolysis.

• Authors: Hiroshi Matsuzaki, Yuhki Koga, Aiko Suminoe, Utako Oba, Tomohito Takimoto, Toshiro Hara
• Journal: Case reports in oncology (Case Rep Oncol) Vol. 6 Issue 2 Pg. 397-402 ( 2013) ISSN: 1662-6575 [Print] Switzerland
• PMID: 24019778 (Publication Type: Case Reports)