Behavioural and psychological symptoms of dementia in an Alzheimer's disease case successfully treated with natural medicine: association with gonadotropins.

Abstract

Pharmacotherapies for the behavioural and psychological symptoms of dementia are limited; novel agents for the symptoms are still needed. Herein, we report the case of an 80-year-old male patient with Alzheimer's disease whose severe agitation, insomnia and sexual delusions were successfully treated with a traditional natural Japanese (Kampo) medicine, keishi-ka-ryukotsu-borei-to. We found that administrating keishi-ka-ryukotsu-borei-to increased his serum luteinizing hormone level, which could be inversely associated with his behavioural and psychological symptoms. This report suggests that keishi-ka-ryukotsu-borei-to is a possible alternative treatment for the behavioural and psychological symptoms of dementia, especially sexual delusions.

• Authors: Tomihisa Niitsu, Hideki Okamoto, Masaomi Iyo
• Journal: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society (Psychogeriatrics) Vol. 13 Issue 2 Pg. 124-7 (Jun 2013) ISSN: 1479-8301 [Electronic] England
• PMID: 23909971 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 The Authors. Psychogeriatrics © 2013 Japanese Psychogeriatric Society.

Chemical References

• Drugs, Chinese Herbal
• Gonadotropins
• saiko-ka-ryukotsu-borei-to
• Testosterone
• Luteinizing Hormone

Topics

• Aged, 80 and over
• Alzheimer Disease (complications, psychology)
• Behavioral Symptoms (drug therapy, etiology, psychology)
• Delusions (etiology, psychology)
• Dementia (complications, psychology)
• Drugs, Chinese Herbal (therapeutic use)
• Gonadotropins (blood)
• Humans
• Luteinizing Hormone (blood)
• Male
• Mental Status Schedule
• Neuropsychological Tests
• Psychomotor Agitation (etiology, psychology)
• Sleep Initiation and Maintenance Disorders (etiology, psychology)
• Testosterone (blood)
• Treatment Outcome