Abstract | BACKGROUND: Emerging evidence suggests that disturbances in the blood-brain barrier (BBB) may be pivotal to the pathogenesis and pathology of vascular-based neurodegenerative disorders. Studies suggest that heightened systemic and central inflammations are associated with BBB dysfunction. This study investigated the effect of the anti-inflammatory nutraceuticals garlic extract-aged (GEA), alpha lipoic acid (ALA), niacin, and nicotinamide (NA) in a murine dietary-induced model of BBB dysfunction. METHODS: RESULTS: Brain parenchymal abundance of IgG and apoB lipoproteins was markedly exaggerated in mice maintained on the SFA diet concomitant with significantly increased GFAP and COX-2, and reduced systemic anti-oxidative status. The nutraceutical GEA, ALA, niacin, and NA completely prevented the SFA-induced disturbances of BBB and normalized the measures of neurovascular inflammation and oxidative stress. CONCLUSIONS: The anti-inflammatory nutraceutical agents GEA, ALA, niacin, or NA are potent inhibitors of dietary fat-induced disturbances of BBB induced by systemic inflammations.
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Authors | Ryusuke Takechi, Menuka M Pallebage-Gamarallage, Virginie Lam, Corey Giles, John C Mamo |
Journal | Journal of neuroinflammation
(J Neuroinflammation)
Vol. 10
Pg. 73
(Jun 19 2013)
ISSN: 1742-2094 [Electronic] England |
PMID | 23782872
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Apolipoproteins A
- Dietary Fats
- Fatty Acids
- Glial Fibrillary Acidic Protein
- Immunoglobulin G
- Lipids
- Niacin
- Cyclooxygenase 2
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Apolipoproteins A
(metabolism)
- Blood-Brain Barrier
(drug effects, physiology)
- Cyclooxygenase 2
(metabolism)
- Diet
- Dietary Fats
(pharmacology)
- Dietary Supplements
- Fatty Acids
(pharmacology)
- Female
- Glial Fibrillary Acidic Protein
(metabolism)
- Immunoglobulin G
(metabolism)
- Inflammation
(pathology)
- Lipids
(blood)
- Mice
- Mice, Inbred C57BL
- Microscopy, Fluorescence
- Niacin
(pharmacology)
- Oxidative Stress
(physiology)
- Weight Gain
(physiology)
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