Prescription behaviours for tigecycline in real-life clinical practice from five European observational studies.

Abstract

OBJECTIVES:

There is limited information on the use of tigecycline in real-life clinical practice. This analysis aims to identify and understand tigecycline prescribing patterns and associated patient outcomes for approved indications.

PATIENTS AND METHODS:

A pooled analysis of patient-level data collected on the prescription of tigecycline in five European observational studies (July 2006 to October 2011) was conducted.

RESULTS:

A total of 1782 patients who received tigecycline were included in the analysis. Of these patients, 61.6% were male, the mean age was 63.4 ± 14.7 years, 56.4% were in intensive care units, 80.2% received previous antibiotic treatment and 91% had one or more comorbid conditions. The mean Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores at the beginning of treatment were 17.7 ± 7.9 and 7.0 ± 4.0, respectively. The majority of patients (58.3%) received tigecycline for treatment of complicated skin and soft-tissue infections (cSSTIs; n = 254) or complicated intra-abdominal infections (cIAIs; n = 785). Tigecycline was given at the standard dose (100 mg plus 50 mg twice daily) to 89.3% of patients for a mean duration of 11.1 ± 6.4 days. The main reasons for prescribing tigecycline were failure of previous therapy (46.1%), broad-spectrum antibiotic coverage (41.4%) and suspicion of a resistant pathogen (39.3%). Tigecycline was prescribed first-line in 36.3% of patients and as monotherapy in 50.4%. Clinical response rates to treatment with tigecycline alone or in combination were 79.6% (183/230; cSSTIs) and 77.4% (567/733; cIAIs).

CONCLUSIONS:

Although tigecycline prescription behaviour showed some heterogeneity across the study sites, these results confirm a role for tigecycline in real-life clinical practice for the treatment of complicated infections, including those in critically ill patients, across Europe.

• Authors: Matteo Bassetti, Christian Eckmann, Klaus Friedrich Bodmann, Hervé Dupont, Wolfgang R Heizmann, Philippe Montravers, Xavier Guirao, Maria Rita Capparella, Damien Simoneau, Miguel Sánchez García
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 68 Suppl 2 Pg. ii5-14 (Jul 2013) ISSN: 1460-2091 [Electronic] England
• PMID: 23772047 (Publication Type: Journal Article, Meta-Analysis, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Tigecycline
• Minocycline

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (therapeutic use)
• Bacterial Infections (drug therapy)
• Drug Prescriptions (statistics & numerical data)
• Europe
• Female
• Humans
• Intraabdominal Infections (drug therapy)
• Male
• Middle Aged
• Minocycline (analogs & derivatives, therapeutic use)
• Skin Diseases, Bacterial (drug therapy)
• Soft Tissue Infections (drug therapy)
• Tigecycline
• Treatment Outcome
• Young Adult