Soft Tissue Infections

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994 relevant articles (117 outcomes, 154 trials/studies) found for this Disease

Description: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)

Also Known As:

Infections, Soft Tissue; Infection, Soft Tissue; Soft Tissue Infection

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses

Infection: 225242

Soft Tissue Infections: 994

Related Diseases

1.	Infection
2.	Pneumonia (Pneumonitis)
3.	Urinary Tract Infections (Urinary Tract Infection)
4.	Respiratory Tract Infections (Respiratory Tract Infection)
5.	Endocarditis

Experts

1.	Jones, Ronald N: 5 articles (05/2007 - 08/2002)
2.	Kaim, Achim H: 5 articles (03/2005 - 12/2002)
3.	Sader, Helio S: 4 articles (05/2007 - 08/2004)
4.	Fritsche, Thomas R: 3 articles (05/2007 - 08/2004)
5.	Iakovlev, V P: 3 articles (01/2005 - 01/2000)
6.	Blatun, L A: 3 articles (01/2005 - 01/2000)
7.	von Schulthess, Gustav K: 3 articles (10/2004 - 12/2002)
8.	Low, Donald E: 2 articles (08/2008 - 01/2005)
9.	Thulin, Pontus: 2 articles (08/2008 - 01/2005)
10.	Norrby-Teglund, Anna: 2 articles (08/2008 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Soft Tissue Infections:

1.	linezolid (Zyvox)FDA Link 05/01/2009 - "CONCLUSION: Linezolid may be considered as a cost-effective treatment for patients with complicated skin and soft-tissue infections suspected to be MRSA related in France." 04/01/2003 - "A severity score for complicated skin and soft tissue infections derived from phase III studies of linezolid." 01/01/2003 - "CONCLUSION: Results from this randomized trial show that linezolid can significantly reduce LOS for patients with complicated skin and soft tissue infections from suspected or confirmed methicillin-resistant staphylococci." 01/01/2008 - "Linezolid was more effective than comparators in patients with skin and soft-tissue infections (OR 1.67 [1.31-2.12]) and bacteraemia (OR 2.07 [1.13-3.78]). " 12/01/2006 - "Comment: impact of linezolid on economic outcomes and determinants of cost in a clinical trial evaluating patients with MRSA complicated skin and soft-tissue infections." Order ALL the reference details at left...
2.	Ciprofloxacin (Cipro)FDA LinkGeneric 04/27/1987 - "This study also demonstrates the efficacy of ciprofloxacin in soft tissue infection." 05/01/1987 - "The clinical efficacy of ciprofloxacin was evaluated with 21 patients with soft tissue infection due mainly to gram-negative aerobic bacteria. " 02/01/2005 - "For the in vivo experiments, 725 +/- 9 MBq [18F]ciprofloxacin was injected intravenously into four patients with microbiologically proven bacterial soft tissue infections of the lower extremities and time-radioactivity curves were recorded in infected and uninfected tissue for 5 h after tracer injection. " 02/01/1990 - "At that time it was realized that although the ciprofloxacin regimen prescribed was a usual dose for a skin and soft-tissue infection, it was excessive for her degree of renal function. " 07/01/1989 - "Treatment of soft tissue infections in gynecology by comparison 3 vs 7 day therapy with ciprofloxacin." Order ALL the reference details at left...
3.	Cefaclor (Ceclor)FDA LinkGeneric 10/01/1985 - "A double-blind comparative study of S6472 and cefaclor (CCL) was conducted to evaluate the therapeutic efficacy, safety and usefulness in the treatment of skin and soft tissue infections. " 01/01/1979 - "Cefaclor appears to be an effective orally absorbed cephalosporin for common skin and soft tissue infections." 01/01/1979 - "In clinical studies of patients with skin and soft tissue infections, cefaclor proved effective. " 01/01/1979 - "Clinical and laboratory studies with cefaclor: efficacy in skin and soft tissue infections." 03/01/1985 - "S6472 was orally administered to 33 patients with skin and soft tissue infections in 2 divided doses. " Order ALL the reference details at left...
4.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/1984 - "Beta-lactam antibiotics are highly effective against most bacteria causing skin and soft tissue infections. " 08/03/1979 - "We found it effective in treating 14 of 17 patients with mild to moderately severe anaerobic or mixed aerobic/anaerobic pleuropulmonary of soft-tissue infections when adjunctive measures (eg, drainage, débridement, and the use of additional antibiotics to treat important aerobic pathogens) were employed. " 06/01/2006 - "cMRSA skin and soft tissue infections can be successfully treated with orally administered antibiotics to which the organism has demonstrable in vitro susceptibility." 03/01/2008 - "STUDY OBJECTIVE: Test the hypotheses that emergency department (ED) visits for skin and soft tissue infections became more frequent during the emergence of community-associated methicillin-resistant Staphylococcus aureus (MRSA), and that antibiotics typically active against community-associated MRSA were chosen increasingly. " 06/01/2006 - "We performed an observational study to determine the effect of alternative, orally administered antibiotics on cMRSA soft tissue infections. " Order ALL the reference details at left...
5.	Clindamycin (Cleocin)FDA LinkGeneric 05/01/1990 - "It is concluded that clindamycin is a safe and effective agent in the treatment of skin and soft-tissue infections." 01/01/1991 - "Numerous studies have demonstrated that single agents, including this combination, are as efficacious as clindamycin plus an aminoglycoside in treating gynecologic soft tissue infections. " 05/01/2009 - "CONCLUSIONS: Empiric treatment of skin and soft-tissue infections with either clindamycin or T/S maximizes the probability that the antibiotic will be active when CA-MRSA prevalence is >10%. " 07/01/2008 - "Clindamycin has been a useful option for treating skin and soft-tissue infections caused by MRSA. " 07/01/2008 - "We conclude, therefore, that clindamycin is not a suitable alternative antibiotic for use in staphylococcal skin and soft tissue infections." Order ALL the reference details at left...
6.	Ofloxacin (Levofloxacin)FDA LinkGeneric 01/01/1991 - "We evaluated the safety and efficacy of ofloxacin administered both by the intravenous route and orally in 26 men with serious skin and soft tissue infection. " 05/01/2004 - "AIMS: The present study addressed the ability of levofloxacin to penetrate into subcutaneous adipose tissues in patients with soft tissue infection. " 01/01/2008 - "[Levofloxacin in complex therapy of patients with skin and soft tissue infections]" 05/01/2004 - "Tissue pharmacokinetics of levofloxacin in human soft tissue infections." 04/01/2003 - "Levofloxacin is a fluoroquinolone antibiotic commonly used to treat respiratory, urinary tract, skin and soft-tissue infections. " Order ALL the reference details at left...
7.	TeicoplaninIBA 09/01/1991 - "In this study, teicoplanin appeared to be safe, efficacious, and convenient for both hospital staff and patients, and potentially cost-effective for the treatment of skin and soft-tissue infections. " 09/01/1994 - "In this study, once daily teicoplanin appeared to be safe and effective therapy for skin and soft tissue infections." 01/01/1988 - "We conclude that this new antibiotic, teicoplanin, is safe and effective in the treatment of skin and soft tissue infections. " 09/01/1994 - "In this study, we examined the efficacy and safety of teicoplanin for parenteral treatment of skin and soft tissue infections caused by gram-positive bacteria. " 09/01/1991 - "To study the efficacy and safety of teicoplanin for skin and soft-tissue infections, 75 patients received teicoplanin intravenously (38) or intramuscularly (37, of which 16 were outpatients). " Order ALL the reference details at left...
8.	Azithromycin (Zithromax)FDA LinkGeneric 04/01/2009 - "PURPOSE: Azithromycin is an azalide class of antibiotic with pharmacodynamics that have made it a valuable agent in the treatment of soft tissue infections. " 05/01/1995 - "Azithromycin given once daily for 3 days has also been shown to be effective in the treatment of respiratory tract and skin and soft tissue infections in children. " 01/01/2003 - "The efficacy of azithromycin for the treatment of skin and soft tissue infections in adults and children is well established. " 04/15/2004 - "Two regimens of azithromycin prophylaxis against community-acquired respiratory and skin/soft-tissue infections among military trainees." 11/01/2001 - "Tolerability of azithromycin oral suspension, 10 mg/kg once daily for 3 days, was assessed in paediatric patients (< or = 18 years) with respiratory or skin and soft-tissue infections. " Order ALL the reference details at left...
9.	Piperacillin FDA Link 01/01/1994 - "Piperacillin/tazobactam seems to be both effective and safe in the treatment of skin and soft tissue infections in patients confined to hospital." 01/01/1991 - "Twenty-five consecutive patients admitted to hospital with severe soft tissue infection were entered into an open trial designed to evaluate safety and efficacy of the drug combination tazobactam/piperacillin. " 01/01/1994 - "Two large multicentre studies recently evaluated the efficacy and safety of piperacillin/tazobactam in the treatment of skin and soft tissue infections in patients in hospital. " 05/01/1995 - "Two multicenter studies recently evaluated the efficacy and safety of piperacillin/tazobactam in the therapy of skin and soft-tissue infections in hospitalized patients. " 01/01/1994 - "Efficacy and safety of piperacillin/tazobactam in skin and soft tissue infections." Order ALL the reference details at left...
10.	tazobactamIBA 01/01/1994 - "Piperacillin/tazobactam seems to be both effective and safe in the treatment of skin and soft tissue infections in patients confined to hospital." 01/01/1991 - "Twenty-five consecutive patients admitted to hospital with severe soft tissue infection were entered into an open trial designed to evaluate safety and efficacy of the drug combination tazobactam/piperacillin. " 01/01/1994 - "Two large multicentre studies recently evaluated the efficacy and safety of piperacillin/tazobactam in the treatment of skin and soft tissue infections in patients in hospital. " 05/01/1995 - "Two multicenter studies recently evaluated the efficacy and safety of piperacillin/tazobactam in the therapy of skin and soft-tissue infections in hospitalized patients. " 01/01/1994 - "Efficacy and safety of piperacillin/tazobactam in skin and soft tissue infections." Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 08/01/2009 - "We report 3 cases of cryptococcal necrotizing soft tissue infection, 2 in renal transplant patients, and 1 in a heart transplant patient, and discuss similar cases from the literature. " 02/01/2009 - "The precise anatomic localization of increased FDG uptake provided by PET/CT enables accurate differentiation between graft and adjacent soft tissue infection leading to more accurate diagnosis and subsequent optimized therapeutic strategy." 01/01/2009 - "One patient had fibular graft and soft tissue infection that caused delayed healing. " 09/01/2008 - "Skin and soft tissue infections in the transplant population." 04/01/2008 - "A review of the literature revealed that Paecilomyces species are an infrequent cause of disease in transplant patients, with skin and soft tissue infections being the most common presentation. " Order ALL the reference details at left...
2.	Oral Administration 12/01/2006 - "The objective of this study was to test the prophylactic effects of oral administration of active hexose correlated compound (AHCC), a natural immunoenhancer, on survival in a mouse model of surgical soft tissue infection. " 01/01/1985 - "Ciprofloxacin may be particularly effective for oral administration in infections requiring prolonged antibiotic therapy, such as bone, joint, and complicated soft tissue infections, and in pulmonary infections in patients with cystic fibrosis." Order ALL the reference details at left...
3.	Transplantation (Transplant Recipients) 02/01/2009 - "We report a case of severe soft tissue infection caused by Cryptococcus neoformans in a renal transplant recipient. " 09/01/2008 - "Interesting and important new findings about skin and soft tissue infections in transplant recipients are the focus of this review." 09/01/2008 - "Solid organ and hematopoietic stem cell transplant recipients are more likely to develop skin and soft tissue infections, which may be caused by common or atypical pathogens. " 10/01/2007 - "Alternaria alternata soft tissue infection in a forearm transplant recipient." 06/01/1996 - "Isolated fungal soft-tissue infections are uncommon but may cause severe morbidity or mortality among transplant recipients and other immunosuppressed patients. " Order ALL the reference details at left...
4.	Injections 06/01/2003 - "An outbreak of Staphylococcus aureus joint and soft-tissue infections occurred after therapeutic injections in an outpatient setting. " 06/01/2003 - "Outbreak of joint and soft-tissue infections associated with injections from a multiple-dose medication vial." 09/01/1999 - "We report four cases of soft tissue infections where the patients were unable to obtain i.v. access and gave injections of drugs using a technique known as 'popping'. " 12/01/1986 - "Successful treatment of osteomyelitis and soft tissue infections in ischemic diabetic legs by local antibiotic injections and the end-diastolic pneumatic compression boot." 08/01/1998 - "CONCLUSIONS: Parenteral injections of illicit drugs can produce infections that present with signs of simple cutaneous abscess and yet unpredictably become extensive necrotizing soft tissue infections. " Order ALL the reference details at left...
5.	Indwelling Catheters (Arterial Line) 12/01/1990 - "Approximately 65% of cases of soft-tissue infection, usually occurring with the use of a Hickman or equivalent indwelling catheter, are associated with the presence on culture of Gram-positive organisms of presumed skin origin. " 12/01/1987 - "Further, to the extent that the indwelling catheter is effective in decubitus ulcer prevention and/or management, long-term catheterization may diminish the risk of bacteremia or death from soft tissue infection. " 12/01/1996 - "The major clinical syndromes caused by these ubiquitous organisms include pulmonary infections, lymphadenitis, otologic infections, skin and soft tissue infections, indwelling catheter infection, and disseminated infections. " Order ALL the reference details at left...

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