Clinical significance of vimentin expression and Her-2 status in patients with gastric carcinoma.

Abstract

OBJECTIVES:

To determine whether vimentin could be used as a marker of gastric carcinomas with more aggressive behavior. To detect the extent of Her-2 status in gastric carcinoma and explore the correlation between vimentin expression and Her-2 status.

METHODS:

Vimentin expression was detected in surgically resected gastric carcinoma tissue specimens from 143 patients by immunohistochemistry. The human epidermal growth factor receptor 2 (Her2) status was evaluated by fluorescence in situ hybridization (FISH). Correlations between vimentin expression, Her-2 status and clinicopathological factors were evaluated using Kaplan-Meier method and Cox multivariate survival models.

RESULTS:

Vimentin expression was significantly correlated with age, advanced stage, poorly differentiated type, venous invasion, hepatic metastasis, and recurrence (p < 0.05). Her-2 gene was amplified in 16 (11.2%) out of the 143 gastric carcinoma tissue specimens. Her-2 status was correlated with advanced cancer, poor differentiation, venous invasion, hepatic metastasis, and recurrence (p < 0.05). The result of multivariate analysis showed that vimentin expression and lymph node metastasis were independent prognostic factors.

CONCLUSIONS:

Vimentin expression in epithelial cells of the surgically resected gastric adenocarcinoma tissue is an independent predictor of short survival, and Her-2 status shows a valuable correlation with clinical parameters.

• Authors: Wenwen Zhao, Lu Yue, Fang Zhou, Congcong Xu, Wanhua Liang, Aihua Sui, Aiping Ding, Wensheng Qiu
• Journal: Clinical and translational science (Clin Transl Sci) Vol. 6 Issue 3 Pg. 184-90 (Jun 2013) ISSN: 1752-8062 [Electronic] United States
• PMID: 23751022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Vimentin
• ERBB2 protein, human
• Receptor, ErbB-2

Topics

• Adult
• Aged
• Aged, 80 and over
• Cytoplasm (metabolism, pathology)
• Female
• Gene Amplification
• Humans
• Lymphatic Metastasis (pathology)
• Male
• Middle Aged
• Multivariate Analysis
• Receptor, ErbB-2 (genetics, metabolism)
• Stomach Neoplasms (genetics, metabolism, pathology)
• Survival Analysis
• Vimentin (metabolism)