Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control.

Abstract	Osteoarthritis (OA) typically generates pain, reduced mobility and reduced quality of life. Most conventional treatments for osteoarthritis, such as non-steroidal anti-inflammatory drugs (NSAIDs) and simple analgesics, have side effects. PCSO-524™, a non polar lipid extract from the New Zealand Green Lipped Mussel, is rich in omega-3 fatty acids and has been shown to reduce inflammation in both animal studies and patient trials. This OA trial examined pain relief changes in relation to quality of life and safety of use for OA patients who took PCSO-524™ compared with patients who took fish oil (containing an industry standard EPA-18% and DHA-12% blend). PCSO-524™ patients showed a statistically significant improvement compared with patients who took fish oil. There was an 89% decrease in their pain symptoms and 91% reported an improved quality of life. Patients treated with fish oil showed significantly less improvement and a greater level of physical discomfort during the study. These results suggest that PCSO-524™ might offer a potential alternative complementary therapy with no side effects for OA patients.
Authors	Marek Zawadzki, Claudia Janosch, Jacek Szechinski
Journal	Marine drugs (Mar Drugs) Vol. 11 Issue 6 Pg. 1920-35 (Jun 05 2013) ISSN: 1660-3397 [Electronic] Switzerland
PMID	23739042 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Fatty Acids, Omega-3 Fish Oils Lipids Docosahexaenoic Acids Eicosapentaenoic Acid
Topics	Aged Animals Complementary Therapies (methods) Docosahexaenoic Acids (adverse effects, therapeutic use) Double-Blind Method Eicosapentaenoic Acid (adverse effects, therapeutic use) Fatty Acids, Omega-3 (adverse effects, isolation & purification, therapeutic use) Female Fish Oils (adverse effects, therapeutic use) Humans Lipids (adverse effects, isolation & purification, therapeutic use) Male Middle Aged Osteoarthritis (complications) Pain (drug therapy, etiology) Perna (chemistry) Quality of Life Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!