Febrile ulceronecrotic Mucha-Habermann disease (pityriasis lichenoides et varioliformis acuta fulminans) associated with parvovirus infection.

Abstract

Febrile ulceronecrotic Mucha-Habermann disease is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta, characterized by a rapidly progressive course with predominant ulceronecrotic lesions associated with fever and systemic manifestations. It carries a great morbidity and is potentially fatal. The exact pathogenesis is not clear, and it has been proposed to be the result of hypersensitivity reaction to an infection. We report a patient with febrile ulceronecrotic Mucha-Habermann disease in a 12-year-old boy in whom the condition was most likely precipitated by parvovirus infection, and he showed a favorable response to a combination of prednisolone with narrow band ultraviolet B (NB-UVB) phototherapy.

• Authors: Arti Nanda, Faisal Alshalfan, Mohammad Al-Otaibi, Humoud Al-Sabah, Jihan M Rajy
• Journal: The American Journal of dermatopathology (Am J Dermatopathol) Vol. 35 Issue 4 Pg. 503-6 (Jun 2013) ISSN: 1533-0311 [Electronic] United States
• PMID: 23612031 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucocorticoids
• Prednisolone

Topics

• Biopsy
• Child
• Combined Modality Therapy
• Glucocorticoids (therapeutic use)
• Humans
• Male
• Parvoviridae Infections (complications, diagnosis, immunology, virology)
• Pityriasis Lichenoides (diagnosis, etiology, immunology, therapy, virology)
• Prednisolone (therapeutic use)
• Skin (immunology, pathology)
• Treatment Outcome
• Ultraviolet Therapy