Febrile Ulceronecrotic Mucha-Habermann disease

A severe variant of pityriasis lichenoides et varioliformis acuta (PLEVA)

Also Known As:

FUMHD; Ulceronecrotic Mucha-Habermann disease

Networked: 29 relevant articles (4 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperpigmentation
2.	Skin Diseases (Skin Disease)
3.	Cicatrix (Scar)
4.	Febrile Ulceronecrotic Mucha-Habermann disease
5.	Superinfection

Experts

1.	Treat, James R: 2 articles (09/2017 - 01/2012)
2.	Brooks, Joel: 1 article (11/2021)
3.	DiLorenzo, Ashley: 1 article (11/2021)
4.	Habeshian, Kaiane: 1 article (11/2021)
5.	Keller, Michael D: 1 article (11/2021)
6.	Kirkorian, A Yasmine: 1 article (11/2021)
7.	Lotke, Michael: 1 article (11/2021)
8.	Wu, Richard: 1 article (11/2021)
9.	Balagula, Eugene: 1 article (01/2021)
10.	Blasiak, Rachel: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Febrile Ulceronecrotic Mucha-Habermann disease:

1.	Methotrexate (Mexate)FDA LinkGeneric 01/01/2015 - "We present an 11-year-old male with Febrile Ulceronecrotic Mucha-Habermann disease who was cured with methotrexate and review the use of methotrexate for this disorder in the pediatric age group with the relevant literature. " 12/01/2020 - "Striking case of Febrile ulceronecrotic Mucha-Habermann disease responding to lymphoplasmapheresis and methotrexate." 11/01/2016 - "Febrile ulceronecrotic Mucha-Habermann disease in an 8-year-old boy responding to methotrexate." 11/01/2015 - "Febrile Ulceronecrotic Mucha-Habermann Disease: Two Cases with Excellent Response to Methotrexate." 01/01/2015 - "Methotrexate Treatment in Children with Febrile Ulceronecrotic Mucha-Habermann Disease: Case Report and Literature Review."
2.	Intravenous Immunoglobulins (IVIG)FDA Link 01/01/2012 - "Only few cases of FUMHD treated with intravenous immunoglobulin have been reported to date. " 07/01/2010 - "Only one case of FUMHD treated by IVIG has been reported to date in literature. " 01/01/2007 - "Intravenous immunoglobulins: a valuable asset in the treatment of a case of septic febrile ulceronecrotic Mucha-Habermann disease." 01/01/2012 - "Febrile ulceronecrotic Mucha-Habermann disease: treatment with infliximab and intravenous immunoglobulins and review of the literature." 07/01/2010 - "We report a case of a 23-year-old man with a steroid-resistant FUMHD treated by intravenous immunoglobulins (IVIG) combined with methotrexate. "
3.	Methylprednisolone FDA LinkGeneric 04/19/2023 - "We report here a case of FUMHD in a 17-year-old male Chinese patient who was treated successfully with a combination therapy of methotrexate, methylprednisolone, and intravenous immunoglobulin. "
4.	Interleukin-2 (IL2)IBA 09/01/2017 - "This report describes a severe case of FUMHD-like eruption associated with clonal leukemic cells that improved with basiliximab, suggesting anti-CD25 therapy as a novel treatment for ulceronecrotic skin disease in the setting of high interleukin-2 levels."
5.	Basiliximab FDA Link 09/01/2017 - "This report describes a severe case of FUMHD-like eruption associated with clonal leukemic cells that improved with basiliximab, suggesting anti-CD25 therapy as a novel treatment for ulceronecrotic skin disease in the setting of high interleukin-2 levels."
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2021 - "A Diagnostically Challenging Case of Febrile Ulceronecrotic Mucha-Habermann Disease in an Adult Female Successfully Treated with Methotrexate and Cyclosporine." 07/01/2014 - "Based on our review of the literature, we are presenting the first case of FUMHD treated with pentoxifylline and the third case of FUMHD successfully treated with cyclosporine. " 07/01/2014 - "Pentoxifylline and cyclosporine in the treatment of febrile ulceronecrotic Mucha-Habermann disease." 07/01/2014 - "We describe two pediatric cases of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) with response to pentoxifylline and cyclosporine therapies. " 05/01/2022 - "Early combination therapy with lower doses of corticosteroids and methotrexate or cyclosporine may be an optimal choice for the treatment of FUMHD."
7.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/01/2023 - "A case of febrile ulceronecrotic Mucha-Habermann disease responsive to systemic corticosteroids." 11/01/2010 - "Febrile ulceronecrotic Mucha-Habermann disease in adult patient successfully treated with systemic corticosteroid." 05/01/2010 - "We also emphasize that FUMHD in children may be successfully treated with a combination of systemic MTX and high-dose corticosteroids." 05/01/2022 - "Early combination therapy with lower doses of corticosteroids and methotrexate or cyclosporine may be an optimal choice for the treatment of FUMHD."
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/01/2014 - "These agents may be of therapeutic benefit in the treatment of FUMHD, in part by suppressing tumor necrosis factor-alpha, which we believe may mediate the disease process. " 04/01/2005 - "Our case demonstrates the clinical and histological continuum between 'classical' PLEVA and FUMHD and points to the potentially pathogenic significance of TNF-alpha. " 01/01/2012 - "We report a case of a 65-year-old woman with a resistant form of FUMHD successfully treated with a tumor necrosis factor-α (TNFα) inhibitor (infliximab). "
9.	SteroidsIBA 07/01/2010 - "We report a case of a 23-year-old man with a steroid-resistant FUMHD treated by intravenous immunoglobulins (IVIG) combined with methotrexate. " 11/21/2022 - "Successful treatment modalities for FUMHD included antibiotics, antivirals, systemic steroids, Methotrexate (MTX), cyclophosphamide, Cyclosporine (CYA), Intravenous Immunoglobulins (IVIG), pentoxifylline, and ultraviolet B phototherapy. "
10.	Pentoxifylline (Trental)FDA LinkGeneric 07/01/2014 - "Based on our review of the literature, we are presenting the first case of FUMHD treated with pentoxifylline and the third case of FUMHD successfully treated with cyclosporine. " 07/01/2014 - "Pentoxifylline and cyclosporine in the treatment of febrile ulceronecrotic Mucha-Habermann disease." 07/01/2014 - "We describe two pediatric cases of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) with response to pentoxifylline and cyclosporine therapies. " 11/21/2022 - "Successful treatment modalities for FUMHD included antibiotics, antivirals, systemic steroids, Methotrexate (MTX), cyclophosphamide, Cyclosporine (CYA), Intravenous Immunoglobulins (IVIG), pentoxifylline, and ultraviolet B phototherapy. "

Therapies and Procedures

1.	Therapeutics 07/01/2016 - "Although different therapeutic options have been used, there is no optimum therapy for FUMHD, and the disease still represents a therapeutic challenge. " 02/01/2016 - "Complete resolution of febrile ulceronecrotic Mucha-Habermann disease following infliximab therapy." 09/01/2017 - "This report describes a severe case of FUMHD-like eruption associated with clonal leukemic cells that improved with basiliximab, suggesting anti-CD25 therapy as a novel treatment for ulceronecrotic skin disease in the setting of high interleukin-2 levels." 07/01/2014 - "We describe two pediatric cases of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) with response to pentoxifylline and cyclosporine therapies. " 04/19/2023 - "We report here a case of FUMHD in a 17-year-old male Chinese patient who was treated successfully with a combination therapy of methotrexate, methylprednisolone, and intravenous immunoglobulin. "
2.	Phototherapy (Light Therapy) 06/01/2013 - "We report a patient with febrile ulceronecrotic Mucha-Habermann disease in a 12-year-old boy in whom the condition was most likely precipitated by parvovirus infection, and he showed a favorable response to a combination of prednisolone with narrow band ultraviolet B (NB-UVB) phototherapy." 11/21/2022 - "Successful treatment modalities for FUMHD included antibiotics, antivirals, systemic steroids, Methotrexate (MTX), cyclophosphamide, Cyclosporine (CYA), Intravenous Immunoglobulins (IVIG), pentoxifylline, and ultraviolet B phototherapy. "
3.	Photopheresis 07/01/2010 - "High-dose immunoglobulines and extracorporeal photochemotherapy in the treatment of febrile ulceronecrotic Mucha-Habermann disease."
4.	Drug Therapy (Chemotherapy) 09/01/2017 - "Her skin disease was refractory to many classic treatments for FUMHD, including methotrexate, and became so severe that concern about superinfection prevented intensification of chemotherapy for her malignancy. "
5.	Debridement 12/01/2002 - "A case of febrile ulceronecrotic Mucha-Habermann disease requiring debridement of necrotic skin and epidermal autograft."