HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Serum adiponectin levels are associated with hepatitis B viral load in overweight to obese hepatitis B virus carriers.

AbstractOBJECTIVE:
This study aimed to investigate the association between serum adiponectin and chronic hepatitis B virus (HBV) infection.
DESIGN AND METHODS:
We conducted a campus-based cross-sectional study in Northern Taiwan, an HBV-endemic country. A total of 506 participants, including 147 chronic HBV-infected individuals and 359 healthy controls, were assessed for anthropometric indices, serum adiponectin levels, serum HBV viral load and markers, serum alanine aminotransferase levels and metabolic factors.
RESULTS:
Older age, male gender, higher alanine aminotransferase, higher body mass index, greater waist circumference, lower fasting glucose, higher triglycerides, and higher adiponectin were associated with chronic HBV infection in univariate analyses. In multivariate analysis, the presence of chronic HBV infection was positively associated with serum adiponectin levels (P < 0.0001) and high adiponectin levels over the 75th percentile (odds ratio, 4.25; 95% confidence interval, 2.36-7.66; P < 0.0001) after adjusting for age, gender, body mass index, and insulin resistance index. Furthermore, serum adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects (P = 0.018).
CONCLUSION:
Although chronic HBV-infected individuals were heavier than healthy controls, they had significantly higher serum adiponectin levels than healthy counterparts. Additionally, adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects. Future research should focus on elucidating adiponectin pathways, which may contribute to the development of adjuvant treatments for chronic HBV infection.
AuthorsChien-Hsieh Chiang, Jin-Shin Lai, Shou-Hung Hung, Long-Teng Lee, Jin-Chuan Sheu, Kuo-Chin Huang
JournalObesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 21 Issue 2 Pg. 291-6 (Feb 2013) ISSN: 1930-739X [Electronic] United States
PMID23404868 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 The Obesity Society.
Chemical References
  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • Insulin
  • Alanine Transaminase
Topics
  • Adiponectin (blood)
  • Adult
  • Alanine Transaminase (blood)
  • Biomarkers (blood)
  • Blood Glucose
  • Body Mass Index
  • Case-Control Studies
  • Cross-Sectional Studies
  • Hepatitis B (blood, complications, virology)
  • Hepatitis B virus (isolation & purification)
  • Humans
  • Insulin (blood)
  • Insulin Resistance
  • Linear Models
  • Multivariate Analysis
  • Obesity (blood, complications, virology)
  • Odds Ratio
  • Overweight (blood, complications, virology)
  • Risk Factors
  • Taiwan
  • Viral Load
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: