Abstract | BACKGROUND: METHODS: A prospective study of all the morbidly obese patients undergoing laparoscopic sleeve gastrectomy as bariatric procedure between October 2007 and May 2011 was performed. RESULTS: A total of 40 patients were included in the study. CRP levels decreased significantly 12 months after surgery (median reduction of 8.9 mg/l; p = 0.001). Serum cortisol levels decreased significantly 6 months after surgery (median reduction of 34.9 μg/dl; p = 0.001). CRP values reached the normal range (<5 mg/l) 1 year after surgery. Referring to cortisol, a significant association was observed with the cardiovascular risk predictor ( triglyceride/ high-density lipoprotein cholesterol ratio) from the 6th month after surgery onward (Pearson correlation coefficient, 0.559; p = 0.008). CONCLUSION: CRP levels are increased preoperatively and in the postoperative course up to 1 year after surgery. Serum cortisol levels remain elevated until the 6th month after surgery. From this moment onward, serum cortisol is associated with the cardiovascular risk predictor reflecting the cardiovascular risk decreasement during the weight loss.
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Authors | Jaime Ruiz-Tovar, Inmaculada Oller, Isabel Galindo, Carolina Llavero, Antonio Arroyo, Alicia Calero, María Diez, Lorea Zubiaga, Rafael Calpena |
Journal | Obesity surgery
(Obes Surg)
Vol. 23
Issue 6
Pg. 764-9
(Jun 2013)
ISSN: 1708-0428 [Electronic] United States |
PMID | 23329374
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Triglycerides
- hemoglobin A1c protein, human
- C-Reactive Protein
- Cholesterol
- Hydrocortisone
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Topics |
- Adult
- Blood Glucose
(metabolism)
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(epidemiology, metabolism, prevention & control)
- Cholesterol
(metabolism)
- Female
- Follow-Up Studies
- Gastric Bypass
(methods)
- Glycated Hemoglobin
(metabolism)
- Homeostasis
- Humans
- Hydrocortisone
(metabolism)
- Insulin Resistance
- Laparoscopy
- Male
- Metabolic Syndrome
(epidemiology, metabolism, prevention & control)
- Middle Aged
- Obesity, Morbid
(epidemiology, metabolism, surgery)
- Postoperative Period
- Preoperative Period
- Prospective Studies
- Risk Factors
- Spain
(epidemiology)
- Treatment Outcome
- Triglycerides
(metabolism)
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