Early and late acute lung injury and their association with distal organ damage in murine malaria.

Abstract

Severe malaria is characterised by cerebral oedema, acute lung injury (ALI) and multiple organ dysfunctions, however, the mechanisms of lung and distal organ damage need to be better clarified. Ninety-six C57BL/6 mice were injected intraperitoneally with 5×10(6)Plasmodium berghei ANKA-infected erythrocytes or saline. At day 1, Plasmodium berghei infected mice presented greater number of areas with alveolar collapse, neutrophil infiltration and interstitial oedema associated with lung mechanics impairment, which was more severe at day 1 than day 5. Lung tumour necrosis factor-α and chemokine (C-X-C motif) ligand 1 levels were higher at day 5 compared to day 1. Lung damage occurred in parallel with distal organ injury at day 1; nevertheless, lung inflammation and the presence of malarial pigment in distal organs were more evident at day 5. In conclusion, ALI develops prior to the onset of cerebral malaria symptoms. Later during the course of infection, the established systemic inflammatory response increases distal organ damage.

• Authors: Mariana C Souza, Johnatas D Silva, Tatiana A Pádua, Vera Luiza Capelozzi, Patricia R M Rocco, Maria das Graças Henriques
• Journal: Respiratory physiology & neurobiology (Respir Physiol Neurobiol) Vol. 186 Issue 1 Pg. 65-72 (Mar 01 2013) ISSN: 1878-1519 [Electronic] Netherlands
• PMID: 23328346 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Cytokines

Topics

• Animals
• Cytokines (biosynthesis)
• Disease Models, Animal
• Lung (immunology, pathology)
• Lung Injury (immunology, microbiology, pathology)
• Malaria, Falciparum (complications, immunology, pathology)
• Mice
• Mice, Inbred C57BL