Abstract | BACKGROUND: STUDY DESIGN: Cross-sectional observational study. SETTING & PARTICIPANTS: 153 stable outpatients with non-dialysis-dependent CKD. PREDICTOR: The primary predictor was FGF-23 level. OUTCOMES: hs-cTnI, hs-cTnT. MEASUREMENTS: FGF-23, hs-cTnI, hs-cTnT; left ventricular mass index (LVMI) assessed by echocardiography; coronary artery calcification (CAC) measured by computed tomography. LVMI and CAC were evaluated as potential mediators of the effect of FGF-23 on hs-cTnI/T. RESULTS: Mean age was 64 ± 12 (SD) years, mean estimated glomerular filtration rate was 34 ± 11 mL/min/1.73 m(2), median FGF-23 level was 120 (25th-75th percentile, 79-223) reference unit (RU)/mL, median hs-cTnI level was 6.5 (25th-75th percentile, 3.5-14.5) pg/mL, and median hs-cTnT level was 16.8 (25th-75th percentile, 11.1-33.9) pg/mL. cTnI and cTnT concentrations were higher than the 99th percentile of a healthy population in 42% and 61% of patients, respectively. In unadjusted and multivariable-adjusted analyses, hs-cTnI/T levels were associated significantly with FGF-23 levels. Adjusting for LVMI, but not CAC, weakened the association of FGF-23 and hs-cTnI/T levels. LIMITATIONS: CONCLUSIONS: Minimally elevated cTnI and cTnT levels, detectable by high-sensitivity assays, are associated with elevated FGF-23 levels in stable outpatients with CKD. FGF-23-associated LVH may contribute to detectable hs-cTnI/T levels observed in non-dialysis-dependent patients with CKD.
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Authors | Kelsey Smith, Christopher deFilippi, Tamara Isakova, Orlando M Gutiérrez, Karen Laliberte, Stephen Seliger, Walter Kelley, Show-Hong Duh, Michael Hise, Robert Christenson, Myles Wolf, James Januzzi |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 61
Issue 1
Pg. 67-73
(Jan 2013)
ISSN: 1523-6838 [Electronic] United States |
PMID | 22883134
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- FGF23 protein, human
- Troponin I
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
|
Topics |
- Aged
- Biomarkers
(blood)
- Comorbidity
- Coronary Artery Disease
(epidemiology)
- Cross-Sectional Studies
- Echocardiography
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
(blood)
- Glomerular Filtration Rate
(physiology)
- Humans
- Hypertrophy, Left Ventricular
(blood, diagnostic imaging, epidemiology)
- Male
- Middle Aged
- Multivariate Analysis
- Prevalence
- Prognosis
- Renal Insufficiency, Chronic
(blood, epidemiology, physiopathology)
- Sensitivity and Specificity
- Troponin I
(blood)
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