Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: a repeated-measure study.

Abstract

BACKGROUND:

Ambient particulate matter (PM) exposure has been associated with short- and long-term effects on cardiovascular disease (CVD). Telomere length (TL) is a biomarker of CVD risk that is modified by inflammation and oxidative stress, two key pathways for PM effects. Whether PM exposure modifies TL is largely unexplored.

OBJECTIVES:

To investigate effects of PM on blood TL in a highly-exposed population.

METHODS:

We measured blood TL in 120 blood samples from truck drivers and 120 blood samples from office workers in Beijing, China. We measured personal PM(2.5) and Elemental Carbon (EC, a tracer of traffic particles) using light-weight monitors. Ambient PM(10) was obtained from local monitoring stations. We used covariate-adjusted regression models to estimate percent changes in TL per an interquartile-range increase in exposure.

RESULTS:

Covariate-adjusted TL was higher in drivers (mean=0.87, 95%CI: 0.74; 1.03) than in office workers (mean=0.79, 95%CI: 0.67; 0.93; p=0.001). In all participants combined, TL increased in association with personal PM(2.5) (+5.2%, 95%CI: 1.5; 9.1; p=0.007), personal EC (+4.9%, 95%CI: 1.2; 8.8; p=0.01), and ambient PM(10) (+7.7%, 95%CI: 3.7; 11.9; p<0.001) on examination days. In contrast, average ambient PM(10) over the 14 days before the examinations was significantly associated with shorter TL (-9.9%, 95%CI: -17.6; -1.5; p=0.02).

CONCLUSIONS:

Short-term exposure to ambient PM is associated with increased blood TL, consistent with TL roles during acute inflammatory responses. Longer exposures may shorten TL as expected after prolonged pro-oxidant exposures. The observed TL alterations may participate in the biological pathways of short- and long-term PM effects.

• Authors: Lifang Hou, Sheng Wang, Chang Dou, Xiao Zhang, Yue Yu, Yinan Zheng, Umakanth Avula, Mirjam Hoxha, Anaité Díaz, John McCracken, Francesco Barretta, Barbara Marinelli, Pier Alberto Bertazzi, Joel Schwartz, Andrea A Baccarelli
• Journal: Environment international (Environ Int) Vol. 48 Pg. 71-7 (Nov 01 2012) ISSN: 1873-6750 [Electronic] Netherlands
• PMID: 22871507 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Particulate Matter
• Reactive Oxygen Species

Topics

• Adult
• Air Pollution (statistics & numerical data)
• Biomarkers (blood)
• Cardiovascular Diseases (epidemiology, metabolism)
• China
• Female
• Humans
• Inhalation Exposure (statistics & numerical data)
• Male
• Middle Aged
• Particulate Matter (analysis)
• Reactive Oxygen Species (metabolism)
• Telomere (physiology)
• Telomere Shortening (physiology)