Abstract | BACKGROUND AND PURPOSE:
Ischemic stroke is a major cause of death worldwide but lacks viable treatment or treatment targets. Monocyte locomotion inhibitory factor ( MLIF) is a small heat-stable pentapeptide produced by Entamoeba histolytica in axenic culture, which is supposed to protect the brain from ischemic injury; the mechanism, however, remains unknown. In this study, we further investigated the mechanism underlying the protective role of MLIF in brain ischemia. METHODS: RESULTS: CONCLUSIONS:
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Authors | Yuefan Zhang, Jun Chen, Fan Li, Dong Li, Qinhui Xiong, Yang Lin, Dazhi Zhang, Xiao-Fan Wang, Pengyuan Yang, Yao-Cheng Rui |
Journal | Stroke
(Stroke)
Vol. 43
Issue 10
Pg. 2764-73
(Oct 2012)
ISSN: 1524-4628 [Electronic] United States |
PMID | 22829547
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- EEF1A1 protein, rat
- Oligopeptides
- Peptide Elongation Factor 1
- monocyte locomotion inhibitory factor
- Nitric Oxide
- Nitric Oxide Synthase Type III
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Topics |
- Animals
- Brain Injuries
(physiopathology, prevention & control)
- Brain Ischemia
(complications, physiopathology)
- Cells, Cultured
- Endothelium, Vascular
(metabolism, pathology)
- In Vitro Techniques
- Infarction, Middle Cerebral Artery
(complications, physiopathology)
- Male
- Models, Animal
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase Type III
(metabolism)
- Oligopeptides
(physiology)
- Peptide Elongation Factor 1
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
(physiology)
- Up-Regulation
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