Multidisciplinary therapy consisting of minimally invasive resection, irradiation, and intra-arterial infusion of 5-fluorouracil for maxillary sinus carcinomas.

Abstract

BACKGROUND:

Current goals for the treatment of maxillary sinus carcinoma include the preservation of vision, eating, communication, and appearance, as well as the achievement of a cure.

METHODS:

Japanese patients (n = 121) with maxillary sinus carcinoma were analyzed retrospectively. All patients underwent multidisciplinary therapy including minimally invasive resection, 20 Gy irradiation, and intra-arterial infusion of 5-fluorouracil.

RESULTS:

The 5- and 10-year overall survival rates were 73% and 68%, respectively. In 97 patients with squamous cell carcinoma (SCC), the 5- and 10-year overall survival rates were 76% and 70%, respectively. All 29 patients with orbital invasion retained the orbital contents, and 21 of these patients demonstrated adequate visual acuity. There were 16 complications, including trismus (5 patients), double vision (5 patients), fistula formation (3 patients), and cataract (3 patients).

CONCLUSION:

A multidisciplinary therapy, consisting of minimally invasive resection, irradiation, and regional chemotherapy, can yield good patient prognosis and quality of life after treatment.

• Authors: Hiroshi Nishino, Minako Takanosawa, Kazumi Kawada, Takeharu Kanazawa, Keiichi Ichimura, Satoru Takahashi, Masanori Nakazawa
• Journal: Head & neck (Head Neck) Vol. 35 Issue 6 Pg. 772-8 (Jun 2013) ISSN: 1097-0347 [Electronic] United States
• PMID: 22730109 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Wiley Periodicals, Inc.

Chemical References

• Antimetabolites, Antineoplastic
• Fluorouracil

Topics

• Antimetabolites, Antineoplastic (therapeutic use)
• Carcinoma (mortality, pathology, therapy)
• Female
• Fluorouracil (therapeutic use)
• Follow-Up Studies
• Humans
• Infusions, Intra-Arterial
• Kaplan-Meier Estimate
• Lymphatic Metastasis
• Male
• Maxillary Sinus (surgery)
• Maxillary Sinus Neoplasms (mortality, pathology, therapy)
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local
• Orbit (pathology)
• Radiotherapy, Adjuvant
• Retrospective Studies
• Survival Rate