Keratin 17 expression correlates with tumor progression and poor prognosis in gastric adenocarcinoma.

Abstract

BACKGROUND:

Keratin 17 (K17) is regarded as a basal/myoepithelial cell keratin and is known to be inducible in activated keratinocytes. The high frequency of K17 expression in pancreaticobiliary nonmucinous adenocarcinoma or basal-like breast carcinoma has previously been described. However, its expression in gastric cancer (GC) is controversial.

METHODS:

We investigated the clinicopathological features and prognostic significance of 192 patients with GC by immunohistochemical staining of tissue microarrays. Analysis of epithelial markers including K17, K14, and K5/6, cell cycle-associated proteins p53, Ki-67, and 14-3-3 sigma, and mucinous phenotype markers including CD10, CDX2, MUC5AC, and MUC6 was performed.

RESULTS:

Cytoplasmic expression of K17 was observed in 95 (49.5%) of 192 patients with GC. K17 expression positively correlated with lymph node metastasis (P = 0.003) and advanced stages of the disease (P = 0.014). K17 expression was significantly correlated with 14-3-3 sigma expression (P < 0.001) and CD10 expression (P = 0.015). The overall survival rates of patients with K17-positive GC were significantly lower than those with negative K17 expression (50.5 vs. 71.1%, P = 0.004). Univariate analysis revealed that K17 expression confers a poor prognosis in patients with GC (P = 0.004), and it was also an independent prognostic factor in multivariate analysis (P = 0.049).

CONCLUSIONS:

K17 expression is correlated with tumor progression in GC and may serve as a biomarker for poor prognosis.

• Authors: Munenori Ide, Toshihide Kato, Kyoichi Ogata, Erito Mochiki, Hiroyuki Kuwano, Tetsunari Oyama
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 19 Issue 11 Pg. 3506-14 (Oct 2012) ISSN: 1534-4681 [Electronic] United States
• PMID: 22695933 (Publication Type: Journal Article)

Chemical References

• 14-3-3 Proteins
• Biomarkers, Tumor
• CDX2 Transcription Factor
• CDX2 protein, human
• Homeodomain Proteins
• Keratin-17
• Ki-67 Antigen
• MUC5AC protein, human
• MUC6 protein, human
• Mucin 5AC
• Mucin-6
• Tumor Suppressor Protein p53
• Exonucleases
• Exoribonucleases
• SFN protein, human
• Neprilysin

Topics

• 14-3-3 Proteins (metabolism)
• Adenocarcinoma (metabolism, secondary)
• Aged
• Biomarkers, Tumor (metabolism)
• CDX2 Transcription Factor
• Disease Progression
• Exonucleases (metabolism)
• Exoribonucleases
• Female
• Homeodomain Proteins (metabolism)
• Humans
• Kaplan-Meier Estimate
• Keratin-17 (metabolism)
• Ki-67 Antigen (metabolism)
• Lymphatic Metastasis
• Male
• Middle Aged
• Mucin 5AC (metabolism)
• Mucin-6 (metabolism)
• Multivariate Analysis
• Neoplasm Staging
• Neprilysin (metabolism)
• Prognosis
• Proportional Hazards Models
• Stomach Neoplasms (metabolism, pathology)
• Tumor Suppressor Protein p53 (metabolism)