Abstract | PURPOSE: MATERIALS AND METHODS: Consecutive patients of CHB were included. HBV DNA was measured by real-time polymerase chain reaction (PCR). Serum HBsAg was measured by Architect HBsAg. RESULTS: Of the 198 patients enrolled, 166 fulfilled the inclusion criteria (mean age 43 ± 14 years, 87% males) and the median HBV DNA was 1.7 × 10 3 (range 6.0-1.1 × 10 8 ) IU/ml. Median HBsAg was 8.7 × 10 3 (range 5.0-3.2 × 10 5) IU/ml. Overall correlation between HBV DNA and HBsAg was weak but significant (Spearman ρ = 0.443, P < 0.01). Correlation in HBe antigen-positive group was better (ρ = 0.402, P < 0.01) in comparison to HBe antigen-negative group (ρ = 0.193 P = 0.05). Good correlation existed in treatment-naïve group (ρ = 0.538, P < 0.01) .Correlation was regardless of normal or raised alanine transaminase (ALT). Eighty (48%) patients had high HBV DNA (≥ 2000 IU/ml). Correlation in high DNA group was significant (P < 0.01). The best cut-off of HBsAg for diagnosing high DNA is 3.36 ×10 3 IU/ml. CONCLUSIONS: Serum HBsAg correlates with HBV DNA in CHB patients, especially in high serum HBV DNA, HBe antigen-positive and treatment-naïve group. HBsAg levels can be used for predicting high serum HBV DNA levels.
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Authors | E Gupta, A Kumar, A Choudhary, M Kumar, S K Sarin |
Journal | Indian journal of medical microbiology
(Indian J Med Microbiol)
2012 Apr-Jun
Vol. 30
Issue 2
Pg. 150-4
ISSN: 1998-3646 [Electronic] United States |
PMID | 22664428
(Publication Type: Journal Article)
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Chemical References |
- DNA, Viral
- Hepatitis B Surface Antigens
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Cross-Sectional Studies
- DNA, Viral
(blood)
- Hepatitis B Surface Antigens
(blood)
- Hepatitis B, Chronic
(virology)
- Humans
- Immunoassay
- Male
- Middle Aged
- Prospective Studies
- Real-Time Polymerase Chain Reaction
- Serum
(chemistry, virology)
- Statistics as Topic
- Young Adult
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