Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol.

Abstract

The aim of this study is to investigate the correlation between E400A polymorphisms of interleukin-4 receptor α chain (IL-4Rα) and lipid metabolism. Genomic DNA from 121 type 2 diabetes mellitus (T2DM) patients and 113 non-diabetic, non-obese control study subjects were extracted, and their IL-4Rα E400A polymorphisms were analyzed by PCR-RFLP. The correlation between IL-4Rα E400A genotypes and study subjects' lipid profile was then examined. Significant associations of the IL-4Rα E400A genotypes and high density lipoprotein-cholesterol (HDL-C) levels among control individuals (p=0.007), as well as among the T2DM patients (p=0.029), were observed. Significant correlations between IL-4Rα E400A genotypes with blood pressure, as well as with blood urea nitrogen, were also observed in control subjects. Our results reveal that IL-4Rα may play certain roles in the lipid metabolism of Taiwanese population and suggest a novel link between lipid metabolism and the cytokine receptor.

• Authors: Yih-Hsin Chang, Chien-Ning Huang, Ming-Yuh Shiau
• Journal: Cytokine (Cytokine) Vol. 59 Issue 2 Pg. 309-12 (Aug 2012) ISSN: 1096-0023 [Electronic] England
• PMID: 22633285 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Cholesterol, HDL
• IL4R protein, human
• Interleukin-4 Receptor alpha Subunit

Topics

• Case-Control Studies
• Cholesterol, HDL (blood)
• Demography
• Diabetes Mellitus, Type 2 (blood, genetics)
• Female
• Gene Frequency (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Interleukin-4 Receptor alpha Subunit (genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)