Abstract | OBJECTIVE: DESIGN: Experiments using endometriotic tissues and primary cells. SETTING: Division of Reproductive Biology Research, Northwestern University. PATIENT(S): Premenopausal women. INTERVENTION(S): Matched samples of eutopic endometrium and ovarian endometriosis (n = 8 patients) were analyzed by microarray and verified in a separate set of tissues (n = 6 patients). Experiments to define signaling pathways were performed in primary endometriotic stromal cells (n = 12 patients). MAIN OUTCOMES MEASURE(S): Using a genome-wide in vivo approach, we identified 1,366 differentially expressed genes and a new gene network favoring increased glucocorticoid levels and action in endometriosis. RESULT(S): CONCLUSION(S): The proinflammatory milieu of the endometriotic lesion stimulates cortisol synthesis and action in endometriotic lesions.
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Authors | Diana Monsivais, Jeffrey D Bray, Emily Su, Mary Ellen Pavone, Matthew T Dyson, Antonia Navarro, Toshiyuki Kakinuma, Serdar E Bulun |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 98
Issue 1
Pg. 117-25
(Jul 2012)
ISSN: 1556-5653 [Electronic] United States |
PMID | 22521153
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Published by Elsevier Inc. |
Chemical References |
- Eicosanoids
- Glucocorticoids
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Topics |
- Adult
- Case-Control Studies
- Cells, Cultured
- Eicosanoids
(metabolism)
- Endometriosis
(genetics, metabolism, pathology)
- Endometrium
(metabolism, pathology)
- Female
- Gene Expression Profiling
- Glucocorticoids
(metabolism)
- Humans
- Metabolic Networks and Pathways
(genetics)
- Microarray Analysis
- Middle Aged
- Ovarian Diseases
(genetics, metabolism, pathology)
- Up-Regulation
(genetics)
- Young Adult
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