The effect of thyroid disorders on lipid levels and metabolism.

Abstract

Thyroid hormones regulate cholesterol and lipoprotein metabolism, whereas thyroid disorders, including overt and subclinical hypothyroidism, considerably alter lipid profile and promote cardiovascular disease. Good evidence shows that high thyroid-stimulating hormone (TSH) is associated with a nonfavorable lipid profile, although TSH has no cutoff threshold for its association with lipids. Thyromimetics represent a new class of hypolipidemic drugs: their imminent application in patients with severe dyslipidemias, combined or not with statins, will improve the lipid profile, potentially accelerate energy expenditure and, as a consequence, vitally lessen the risk of cardiovascular disease.

• Authors: Leonidas H Duntas, Gabriela Brenta
• Journal: The Medical clinics of North America (Med Clin North Am) Vol. 96 Issue 2 Pg. 269-81 (Mar 2012) ISSN: 1557-9859 [Electronic] United States
• PMID: 22443975 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Cholesterol, LDL
• Lipoproteins, HDL
• Thyroid Hormones
• Triglycerides
• Thyrotropin
• Cholesterol
• Thyroxine

Topics

• Cholesterol (metabolism)
• Cholesterol, LDL (metabolism)
• Coronary Disease (etiology, metabolism, prevention & control)
• Humans
• Hypothyroidism (complications, metabolism)
• Lipid Metabolism
• Lipoproteins, HDL (metabolism)
• Molecular Mimicry
• Risk Factors
• Thyroid Diseases (complications, metabolism)
• Thyroid Hormones (metabolism, therapeutic use)
• Thyrotropin (metabolism)
• Thyroxine (metabolism)
• Triglycerides (metabolism)