Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people.

Abstract

BACKGROUND:

Lipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a large-scale Chinese population.

METHODS:

We evaluated serum lipocalin-2 in a cross-sectional sample of 2519 Chinese aged from 50 to 82 year in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured.

RESULTS:

Serum lipocalin-2 was significantly higher in subjects with isolated impaired fasting glucose, isolated impaired glucose tolerance, combined impaired fasting glucose/impaired glucose tolerance and newly-diagnosed type 2 diabetes than in those with normal glucose regulation. Lipocalin-2 elevation was clearly associated with a higher risk for impaired glucose regulation (OR 1.30 for each 10 ng/ml increase in serum lipocalin-2, 95% CI 1.23-1.62, p = 0.009) after adjustment of age, gender, smoking, alcohol drinking, family history of diabetes, serum CRP, serum adiponectin, serum CXCL5, HOMA-IR, BMI, and waist/hip ratio. The OR for participants with impaired glucose regulation and type 2 diabetes was 1.31 (95% CI 1.21-1.69, p < 0.001).

CONCLUSIONS:

Our findings suggest that elevated serum lipocalin-2 is closely and independently associated with impaired glucose regulation and type 2 diabetes.

• Authors: Ying Huang, Zhen Yang, Zi Ye, Qin Li, Jie Wen, Xiaoming Tao, Lili Chen, Min He, Xuanchun Wang, Bin Lu, Zhaoyun Zhang, Weiwei Zhang, Shen Qu, Renming Hu
• Journal: Cardiovascular diabetology (Cardiovasc Diabetol) Vol. 11 Pg. 11 (Jan 31 2012) ISSN: 1475-2840 [Electronic] England
• PMID: 22292925 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acute-Phase Proteins
• Adipokines
• Blood Glucose
• Inflammation Mediators
• Insulin
• LCN2 protein, human
• Lipids
• Lipocalin-2
• Lipocalins
• Proto-Oncogene Proteins

Topics

• Acute-Phase Proteins
• Adipokines (blood)
• Aged
• Aged, 80 and over
• Asian People
• Blood Glucose (metabolism)
• China
• Chronic Disease
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood, diagnosis, ethnology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Glucose Intolerance (blood, diagnosis, ethnology)
• Humans
• Inflammation (blood, ethnology)
• Inflammation Mediators (metabolism)
• Insulin (blood)
• Insulin Resistance
• Lipids (blood)
• Lipocalin-2
• Lipocalins (blood)
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Odds Ratio
• Phenotype
• Proto-Oncogene Proteins (blood)
• Risk Assessment
• Risk Factors
• Up-Regulation