Study of anti-inflammatory effects of GB-115, a glycine-containing retropeptide cholecystokinin analog.

Abstract

Anti-inflammatory effects of GB-115 compound (N-phenylhexanoyl-glycyl-L-tryptophan amide) injected intraperitoneally in doses of 0.1, 1, and 10 mg/kg were demonstrated on the model of ConA- and carrageenan-induced inflammation. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltration of the perivascular space of the brain tissue. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg suppressed generation of active oxygen forms by neutrophils in the chemiluminescence test.

• Authors: E V Shipaeva, L P Kovalenko, A V Sorokina, G I Kovalev, A V Tallerova, L G Kolik, T A Gudasheva, A D Durnev, S B Seredenin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 150 Issue 5 Pg. 599-602 (Mar 2011) ISSN: 1573-8221 [Electronic] United States
• PMID: 22235394 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Dipeptides
• GB-115
• Reactive Oxygen Species
• Concanavalin A
• Carrageenan
• Cholecystokinin

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Brain (drug effects, pathology)
• Carrageenan (adverse effects, pharmacology)
• Cholecystokinin (analogs & derivatives, pharmacology)
• Concanavalin A (adverse effects, pharmacology)
• Dipeptides (pharmacology)
• Encephalomyelitis, Autoimmune, Experimental (drug therapy, pathology)
• Female
• Inflammation (drug therapy)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Neutrophil Infiltration (drug effects)
• Neutrophils (drug effects)
• Rats
• Reactive Oxygen Species (metabolism)
• Thymus Gland (drug effects)