Anthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial activities in vitro.

Abstract	Anthemis wiedemanniana is known in folk medicine for the treatment of microbial infections, cancer and also urinary and pulmonary problems. In this study, the chemical composition of the essential oil from A. wiedemanniana was evaluated and its antibacterial activity was tested against 10 bacterial strains. The oil was also tested for its potentiality to inhibit nitric oxide production in RAW 264.7 macrophages and for its cytotoxicity against four human cancer cell lines. A. wiedemanniana oil, rich of oxygenated monoterpenes (25.4%), showed a good antibacterial activity against Gram-positive bacteria and a good activity against the two Gram-negative bacteria, Escherichia coli and Proteus vulgaris. Besides that, it exhibited a high inhibitory effect on the LPS-induced nitrite production and a strong cytotoxic activity, especially against amelanotic melanoma (C32) and large lung cell carcinoma (COR-L23) cell lines.
Authors	Filomena Conforti, Federica Menichini, Carmen Formisano, Daniela Rigano, Felice Senatore, Maurizio Bruno, Sergio Rosselli, Sezgin Celik
Journal	Natural product research (Nat Prod Res) Vol. 26 Issue 17 Pg. 1594-601 ( 2012) ISSN: 1478-6427 [Electronic] England
PMID	22124231 (Publication Type: Journal Article)
Chemical References	Anti-Bacterial Agents Antineoplastic Agents, Phytogenic Lipopolysaccharides Monoterpenes Nitrites Oils, Volatile
Topics	Animals Anthemis (chemistry) Anti-Bacterial Agents (adverse effects, chemistry, pharmacology) Antineoplastic Agents, Phytogenic (adverse effects, chemistry, pharmacology) Cell Line Cell Line, Tumor Cell Proliferation (drug effects) Escherichia coli (drug effects) Gram-Positive Bacteria (drug effects) Humans Lipopolysaccharides (pharmacology) Mice Microbial Sensitivity Tests Monoterpenes (chemistry) Nitrites (metabolism) Oils, Volatile (adverse effects, chemistry, pharmacology) Proteus (drug effects)

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