Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury.

Abstract

Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury.

• Authors: Amy E B Packard, Jason C Hedges, Frances R Bahjat, Susan L Stevens, Michael J Conlin, Andres M Salazar, Mary P Stenzel-Poore
• Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 32 Issue 2 Pg. 242-7 (Feb 2012) ISSN: 1559-7016 [Electronic] United States
• PMID: 22086194 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Cytokines
• Interferon Inducers
• Neuroprotective Agents
• Poly I-C

Topics

• Animals
• Brain (drug effects, physiopathology)
• Brain Ischemia (physiopathology, prevention & control)
• Cells, Cultured
• Cytokines (blood)
• Interferon Inducers (therapeutic use)
• Ischemic Preconditioning (methods)
• Kidney (drug effects, physiopathology)
• Kidney Diseases (physiopathology, prevention & control)
• Male
• Mice
• Mice, Inbred C57BL
• Neuroprotective Agents (therapeutic use)
• Poly I-C (therapeutic use)
• Reperfusion Injury (physiopathology, prevention & control)