The role of Chlamydia trachomatis polymorphic membrane proteins in inflammation and sequelae among women with pelvic inflammatory disease.

Abstract

Chlamydia trachomatis polymorphic membrane proteins (Pmps) may increase genital tract inflammation and play a role in virulence. Antibody levels for PmpA, PmpD, and PmpI, measured in densitometric units, were assessed among a pilot sample of 40 C. trachomatis-infected women with mild-to-moderate clinical PID. Women who expressed antibodies to PmpA were less likely to achieve pregnancy (40.0% versus 85.7%; P = 0.042) and less likely to have a live birth (0.0% versus 80.0%; P = 0.005) compared to women who did not express antibody to PmpA. Women who expressed antibodies to PmpI were more likely to have upper genital tract infection (61.5% versus 20.0%; P = 0.026). However, seropositivity to PmpI and PmpD did not modify the risk of reproductive sequelae or inflammation. Seropositivity to chlamydial PmpA may represent a biomarker of increased risk of sequelae secondary to infection with C. trachomatis.

• Authors: Brandie D Taylor, Toni Darville, Chun Tan, Patrik M Bavoil, Roberta B Ness, Catherine L Haggerty
• Journal: Infectious diseases in obstetrics and gynecology (Infect Dis Obstet Gynecol) Vol. 2011 Pg. 989762 ( 2011) ISSN: 1098-0997 [Electronic] Egypt
• PMID: 22028586 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Brandie D. Taylor et al.

Chemical References

• Antibodies, Bacterial
• Bacterial Outer Membrane Proteins

Topics

• Adult
• Antibodies, Bacterial (immunology)
• Bacterial Outer Membrane Proteins (immunology)
• Chlamydia Infections (immunology)
• Chlamydia trachomatis (immunology)
• Female
• Fertility
• Humans
• Pelvic Inflammatory Disease (immunology)
• Pilot Projects
• Pregnancy
• Pregnancy Outcome