Immunotherapy of collagen-induced arthritis by a T-cell antiproliferative molecule.

Abstract

The present study describes a novel experimental immunotherapeutic methodology for the reduction of inflammatory synovitis that is noted in an animal model of rheumatoid arthritis. The reduction in inflammation is noted in the animals administered a contra-interleukin-2 (IL-2) cytokine secreted by a cloned T-cell line. The mechanism of reduction of inflammation by this cytokine is through the inhibition of activation and differentiation of T lymphocytes. The cytokine inhibits the in vitro mitogen activation of T-cell lymphocytes as well as antigen-specific activation of a collagen type II specific T-cell line. In addition, decreased levels of messenger RNA coding for interleukin-2 are noted in T lymphocytes and IL-2 activation of the collagen type II specific cell line is inhibited by the contra-IL-2 cytokine. This initial description of a reduction in inflammation by a contra-IL-2 lymphokine suggests that immunoregulatory biologic molecules that are antagonists to IL-2 may be useful for the experimental immunotherapy of cartilage connective tissue pathology.

• Authors: D J Spannaus-Martin, R Holmdahl, T F Kresina
• Journal: The American journal of pathology (Am J Pathol) Vol. 137 Issue 2 Pg. 331-9 (Aug 1990) ISSN: 0002-9440 [Print] United States
• PMID: 2201199 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biological Factors
• Cytokines
• Interleukin-2
• RNA, Messenger
• Collagen

Topics

• Animals
• Arthritis (drug therapy)
• Arthritis, Experimental (chemically induced, drug therapy, metabolism)
• Biological Factors (pharmacology, therapeutic use)
• Blast Crisis (pathology)
• Cell Differentiation (drug effects)
• Cell Line
• Collagen
• Cytokines
• Hybridomas (metabolism, pathology)
• Interleukin-2 (antagonists & inhibitors, genetics, metabolism)
• Lymphocyte Activation (drug effects)
• Male
• Mice
• RNA, Messenger (drug effects, genetics, metabolism)
• T-Lymphocytes (cytology, metabolism)
• Thymoma (metabolism, pathology)