Higher plasma renin activity is a risk factor for total mortality in older Japanese individuals: the Takahata study.

Abstract

Plasma renin activity (PRA) is accepted as a marker for increased risk of cardiovascular diseases. However, the association between PRA and total mortality has not been fully explored in a general population. We here examined whether PRA is associated with increased total mortality in a general Japanese population. The participants of the Takahata study (3502 subjects; age, 62.5 ± 10.4 years), a population-based, longitudinal study of Japanese held from 2004 to 2006, were enrolled and followed up for up to 7 years. The incidence of death and causes of death were monitored annually to the end of 2010 (median follow-up, 2280 days). During the follow-up period, 143 subjects died. Kaplan-Meier analysis showed a significantly increased risk for total mortality in subjects with higher PRA (log-rank P < .001). Cox proportional hazard model analyses with adjustment for factors correlated with PRA (age, sex, weight, diastolic blood pressure, high-density lipoprotein cholesterol, uric acid, B-type natriuretic peptide, serum total protein, antihypertensive treatment, and diabetes) showed that higher PRA was associated with increased total mortality in linear regression models (per 1 increase in log 10 × PRA [nanograms per milliliter per hour]: hazard ratio, 2.12; 95% confidence interval, 1.47-3.06), between groups of patients stratified by quartiles of PRA (highest vs lowest quartile: 2.63, 1.57-4.41) and in subjects with high (≥ 2.0 ng/[mL h]) vs low (<2.0 ng/[mL h]) PRA (1.97, 1.37-2.83). Higher PRA was a significant and independent risk factor for increased total mortality in this Japanese population and may be a marker for subjects at an increased risk of total mortality.

• Authors: Makoto Daimon, Tsuneo Konta, Toshihide Oizumi, Shigeru Karasawa, Wataru Kaino, Kaoru Takase, Yumi Jimbu, Kiriko Wada, Wataru Kameda, Shinji Susa, Takafumi Saito, Isao Kubota, Takamasa Kayama, Takeo Kato
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 61 Issue 4 Pg. 504-11 (Apr 2012) ISSN: 1532-8600 [Electronic] United States
• PMID: 22001336 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Blood Proteins
• Natriuretic Peptide, Brain
• Uric Acid
• Cholesterol
• Renin

Topics

• Blood Pressure (physiology)
• Blood Proteins (analysis)
• Body Weight (physiology)
• Cholesterol (blood)
• Cohort Studies
• Cross-Sectional Studies
• Female
• Humans
• Japan (epidemiology)
• Kaplan-Meier Estimate
• Linear Models
• Male
• Middle Aged
• Mortality
• Natriuretic Peptide, Brain (blood)
• Prospective Studies
• Renin (blood)
• Uric Acid (blood)