Abstract | BACKGROUND AND OBJECTIVE: PATIENTS: METHODS: Retrospective review of medical records with registration of demography, co-morbidity, bacteriological, biochemical and clinical findings, and Child-Turcotte-Pugh scores. The primary outcome was 30-day mortality. RESULTS: Mortality was significantly higher in patients with chronic liver disease (mortality rate ratio 2.2; 95% confidence interval 1.2-3.9) and it was correlated to Child-Turcotte-Pugh scores. CRP levels were not different between the three Child-Turcotte-Pugh classes (p = 0.33), and no linear correlation with 30-day mortality was observed. CONCLUSION: Mortality associated with bacteremia is increased in patients with chronic liver disease and it is correlated with Child-Turcotte-Pugh score. The prognostic information of initial CRP levels in patients with chronic liver disease is weak. The clinical management of patients with chronic liver disease and suspected infection should initiate antimicrobial therapy based on clinical, radiological and microbiological findings, whereas the measurement of CRP in bacteremia is less helpful as compared with patients without liver disease.
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Authors | Sine H Janum, Morten Søvsø, Kim O Gradel, Henrik C Schønheyder, Henrik Nielsen |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 46
Issue 12
Pg. 1478-83
(Dec 2011)
ISSN: 1502-7708 [Electronic] England |
PMID | 21905978
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Bacteremia
(blood, complications, mortality)
- C-Reactive Protein
(metabolism)
- Chronic Disease
- Female
- Humans
- Liver Diseases
(blood, complications, mortality)
- Male
- Middle Aged
- Predictive Value of Tests
- Proportional Hazards Models
- Retrospective Studies
- Severity of Illness Index
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