Abstract | AIMS: METHODS AND RESULTS: We quantified and correlated angiopoietin-1 (Ang-1), Ang-2 and Tie-2 expression in sections of normal human breast, benign and premalignant hyperplastic tissue, pre-invasive and invasive cancer, and compared these findings with our previously published data on vascular endothelial growth factor ( VEGF) and microvessel density (MVD) in the same samples. A breast cancer tissue microarray was used to evaluate the prognostic value of these factors. Histological analysis revealed a significant decrease in Ang-1 expression (P = 0.001) and an inverse correlation with MVD (r = -0.442, P = 0.008) and VEGF (r = -0.510, P = 0.002) in the non-invasive lesions. In contrast Ang-2 expression increased significantly (P = 0.0004) with increasing severity of lesion and correlated with MVD (r = 0.570; P = 0.0002), while Tie-2 expression remained relatively unchanged. Expression of all three factors was reduced in invasive breast cancer and did not correlate with oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), lymph node status or tumour grade. CONCLUSIONS:
|
Authors | Carolyn A Staton, Leslie Hoh, Alice Baldwin, Lucy Shaw, Jenny Globe, Simon S Cross, Malcolm W Reed, Nicola J Brown |
Journal | Histopathology
(Histopathology)
Vol. 59
Issue 2
Pg. 256-63
(Aug 2011)
ISSN: 1365-2559 [Electronic] England |
PMID | 21884204
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2011 Blackwell Publishing Limited. |
Chemical References |
- ANGPT1 protein, human
- Angiopoietin-1
- Angiopoietin-2
- Biomarkers, Tumor
- Receptor, TIE-2
|
Topics |
- Angiopoietin-1
(metabolism)
- Angiopoietin-2
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Breast
(metabolism, pathology)
- Breast Neoplasms
(metabolism, pathology)
- Carcinoma, Ductal, Breast
(metabolism, secondary)
- Carcinoma, Intraductal, Noninfiltrating
- Female
- Humans
- Hyperplasia
- Precancerous Conditions
(metabolism, pathology)
- Receptor, TIE-2
(metabolism)
- Tissue Array Analysis
|