TIE-2 Receptor (Receptor, TIE 2)

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81 relevant articles (0 outcomes, 12 trials/studies) found for this Bio-Agent

Description: A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).

Also Known As:

Receptor, TIE 2; Receptor, TIE-2; Angiopoietin Receptor Tie-2; TIE-2-RTK; TIE2 Tyrosine Kinase; Tek Receptor; Tie2 Receptor; Angiopoietin Receptor Tie 2; Receptor Tie-2, Angiopoietin; Receptor, Tek; Receptor, Tie2; TIE 2 Receptor Tyrosine Kinase; Tie-2, Angiopoietin Receptor; Tyrosine Kinase, TIE2; TIE-2 Receptor Tyrosine Kinase

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24340

Transferases: 3170

Phosphotransferases: 14916

Phosphotransferases (Alcohol Group Acceptor)

Protein Kinases: 5282

Protein-Tyrosine Kinases: 5691

Receptor Protein-Tyrosine Kinases: 237

TIE Receptors: 20

TIE-2 Receptor: 81

zebrafish tie2 protein

Amino Acids, Peptides, and Proteins

Proteins: 56522

Membrane Proteins: 4214

Cell Surface Receptors: 633

Receptor Protein-Tyrosine Kinases: 237

TIE Receptors: 20

TIE-2 Receptor: 81

zebrafish tie2 protein

Experts

1.	Lip, G Y H: 3 articles (10/2005 - 07/2003)
2.	Wang, Chunling: 2 articles (01/2006 - 01/2005)
3.	Xiu, Ruijuan: 2 articles (01/2006 - 01/2005)
4.	Fu, Panfeng: 2 articles (01/2006 - 01/2005)
5.	Blann, Andrew D: 2 articles (10/2004 - 02/2004)
6.	Lip, Gregory Y H: 2 articles (10/2004 - 02/2004)
7.	Kim, Duk-Kyung: 1 article (06/2008)
8.	Suh, Yeon-Lim: 1 article (06/2008)
9.	Lee, Jung-Sun: 1 article (06/2008)
10.	Koh, Gou Young: 1 article (06/2008)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2006 - "Many studies showed that disrupting the ANGPT/TEK receptor pathway could inhibit the growth of a number of murine tumors and human tumors" 06/07/2005 - "Previous studies with intrabodies had demonstrated that the Tie-2 receptor pathway was essential for tumor growth" 05/01/2008 - "BACKGROUND: Cellular events mediated by the Tie2 receptor are important to tumor neovascularization" 12/01/2007 - "A subset of monocytes that express the angiopoietin receptor Tie2 play an important role in tumor angiogenesis" 09/01/2005 - "Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) are selectively recruited to spontaneous and orthotopic tumors, (3) promote angiogenesis in a paracrine manner, and (4) account for most of the proangiogenic activity of myeloid cells in tumors" Get all the results and reference details, order at left...
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 05/01/2001 - "In this study we examined the potential role of angiopoietins and the Tie2 receptor in vascular changes of psoriasis" 03/01/2005 - "Recently, a role for the angiopoietin signaling system in psoriasis has been suggested by studies that demonstrate an up-regulation of the tyrosine kinase receptor Tie2 (also known as Tek) as well as angiopoietin-1 and angiopoietin-2 in human psoriatic lesions" Get all the results and reference details, order at left...
3.	Carcinoma (Carcinomatosis) 04/01/2006 - "Expression of angiopoietin 1, 2 and their common receptor Tie2 in human gastric carcinoma: implication for angiogenesis." 11/01/2000 - "The expression of angiopoietins and their receptor Tie-2 in human prostate carcinoma." 02/01/2005 - "Our results show that the Tie-2 receptor pathway is essential for both SLK sarcoma and SW1222 colon carcinoma xenograft growth" 12/01/2002 - "Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia." 04/01/2005 - "Comparison of the prognosis indication of VEGFR-1 and VEGFR-2 and Tie2 receptor expression in breast carcinoma." Get all the results and reference details, order at left...
4.	Hypertension (High Blood Pressure) 06/01/2008 - "Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor." 10/01/2005 - "Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)]." Get all the results and reference details, order at left...
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/01/2002 - "Soluble Tie-2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma." 08/01/2002 - "BACKGROUND: This study assessed two circulating angiogenic receptors as tumor markers in patients with head and neck squamous cell carcinoma (HNSCC): soluble vascular endothelial factor growth receptor-1 (sVEGFR1) and soluble Tie-2 receptor (sTie2R)" 04/01/2002 - "Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth." Get all the results and reference details, order at left...
51 Diseases and 81 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Angiopoietin-1
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Angiopoietin-2
4.	Angiopoietins
5.	Protein-Tyrosine Kinases (Tyrosine Kinase)
6.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
7.	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)
8.	Retinaldehyde (Retinal)
9.	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
10.	Biological Markers (Surrogate Marker)
38 Drugs and Important Bio-Agents and 54 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Light Coagulation
4.	Lasers (Laser)
4 Therapies and Procedures and 3 more articles analyzed in the Research Interface, order at left...

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