[A case of interstitial pneumonia induced by CPT-11 for local recurrence of rectal cancer].

Abstract

A 60-year-old man underwent total pelvic exenteration for rectal cancer and urinary bladder invasion.He received adjuvant chemotherapy with S-1 and PSK.Because of local recurrence in the 4th postoperative month, he underwent FOLFIRI therapy followed by mFOLFOX6 therapy.After an adverse reaction occurred for OHP, CPT-11 therapy was performed.After 1 course of CPT-11 therapy, he complained of dyspnea and chest pain.We suspected drug-induced interstitial pneumonia, and stopped chemotherapy.He still complained dyspnea, and was treated with PSL.Once dyspnea improved, he gradually deteriorated and was admitted to the hospital.He was given oxygen and steroid pulse therapy, but died of respiratory failure.

• Authors: Eriko Katsuta, Jun Kaneko, Yasunori Someno, Morihito Saguchi, Haruhiko Aoyagi, Tsuyoshi Yoshida, Taro Takahata, Kumi Hasegawa, Setsuo Hamada, Shizuaki Maejima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 7 Pg. 1225-7 (Jul 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 21772118 (Publication Type: Case Reports, Journal Article)

Chemical References

• Irinotecan
• Camptothecin

Topics

• Camptothecin (adverse effects, analogs & derivatives, therapeutic use)
• Combined Modality Therapy
• Fatal Outcome
• Humans
• Irinotecan
• Lung Diseases, Interstitial (chemically induced)
• Male
• Middle Aged
• Rectal Neoplasms (drug therapy, surgery)
• Recurrence