Abstract | AIM: METHODS: Male Koletsky rats were treated with azilsartan (2 mg/kg/day) over 3 weeks. Blood pressure was measured by tail-cuff. Blood biochemical and hormonal parameters were determined by enzymatic or ELISA methods. Gene expression was assessed by RT-PCR. RESULTS: CONCLUSIONS: These results show the insulin-sensitizing effect of azilsartan in obese Koletsky rats. This effect is independent of decreases in food intake and BW increase or of the activation of adipose PPARγ. Our findings indicate the possible usefulness of azilsartan in the treatment of metabolic syndrome.
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Authors | M Zhao, Y Li, J Wang, K Ebihara, X Rong, K Hosoda, T Tomita, K Nakao |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 13
Issue 12
Pg. 1123-9
(Dec 2011)
ISSN: 1463-1326 [Electronic] England |
PMID | 21749604
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 Blackwell Publishing Ltd. |
Chemical References |
- Antihypertensive Agents
- Benzimidazoles
- Blood Glucose
- Insulin
- Oxadiazoles
- PPAR gamma
- azilsartan
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Topics |
- Animals
- Antihypertensive Agents
(pharmacology)
- Benzimidazoles
(pharmacology)
- Blood Glucose
(drug effects)
- Blood Pressure
- Enzyme-Linked Immunosorbent Assay
- Hypertension
(complications, drug therapy)
- Insulin
(metabolism)
- Insulin Resistance
- Male
- Obesity
(complications, metabolism)
- Oxadiazoles
(pharmacology)
- PPAR gamma
(metabolism)
- Polymerase Chain Reaction
(methods)
- Rats
- Rats, Inbred SHR
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