Serum level of pigment epithelium-derived factor is a marker of atherosclerosis in humans.

Abstract

OBJECTIVE:

Pigment epithelium-derived factor (PEDF) could play a protective role against atherosclerosis. However, there is no clinical study to examine the relationship between serum level of PEDF and atherosclerosis in humans.

METHODS/RESULTS:

The study involved 317 consecutive outpatients in Kurume University Hospital (220 male and 97 female) with a mean age of 62.1±9.1. We examined whether serum level of PEDF were independently associated with vascular inflammation evaluated by [(18)F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and intima-media thickness (IMT) in carotid artery in humans. Carotid [(18)F]-FDG uptake, an index of vascular inflammation within the atherosclerotic plaques, was measured as standardized uptake value (SUV). Mean serum PEDF level, carotid SUV and IMT values were 13.5±1.1 μg/mL, 1.34±0.19, and 0.71±0.15 mm, respectively. In multiple stepwise regression analysis, estimated glomerular filtration rate (p<0.001), males (p<0.001), homeostasis model assessment of insulin resistance index (p<0.05), heart rate (p<0.05), triglycerides (p<0.05), carotid IMT (p<0.05), waist circumference (p<0.05) and carotid SUV (p<0.05) were independently correlated to PEDF level (R(2)=0.332).

CONCLUSION:

The present study reveals that serum level of PEDF is independently associated with vascular inflammation and IMT, thus suggesting that PEDF level is a novel biomarker that could reflect atherosclerosis in humans.

• Authors: Nobuhiro Tahara, Sho-ichi Yamagishi, Atsuko Tahara, Yoshikazu Nitta, Norihiro Kodama, Minori Mizoguchi, Dilbahar Mohar, Masatoshi Ishibashi, Naofumi Hayabuchi, Tsutomu Imaizumi
• Journal: Atherosclerosis (Atherosclerosis) Vol. 219 Issue 1 Pg. 311-5 (Nov 2011) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 21733518 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers
• Eye Proteins
• Nerve Growth Factors
• Serpins
• pigment epithelium-derived factor
• Fluorodeoxyglucose F18

Topics

• Aged
• Atherosclerosis (blood, diagnosis)
• Biomarkers
• Carotid Arteries (metabolism)
• Carotid Intima-Media Thickness
• Cross-Sectional Studies
• Eye Proteins (blood)
• Female
• Fluorodeoxyglucose F18
• Humans
• Insulin Resistance
• Male
• Middle Aged
• Nerve Growth Factors (blood)
• Positron-Emission Tomography (methods)
• Serpins (blood)